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In vitro evaluation of free radical scavenging potential of Cassia auriculata L.

In vitro evaluation of free radical scavenging potential of Cassia auriculata L.

Free radicals are well documented for playing a dual role in our body as both deleterious and beneficial species. Excess production of free radicals or decrease in antioxidant level leads to oxidative stress. It results in pathological manifestations such as atherosclerosis, cancer, inflammatory condition, diabetes, Alzheimer’s disease and Parkinson’s disease etc. A variety of synthetic medicines employed in the treatment of different diseases that are capable to generate free radicals in body which may cause another disease. In Ayurveda, the plant sources are rich of antioxidants. Phyto-constituents are capable to terminate free radical reactions and prevent our body from oxidative damage with less side effects and compatible to body physiology. Considering the above facts present work deals with evaluation of free radical scavenging potential of Cassia auriculata L plant.the extracts of leaves, stems and fruits were screened invitro, for their possible radical scavenging antioxidant activity by employing 2, 2-diphenyl-1- picryl-hydrazyl (DPPH) and nitric oxide (NO) reducing power with ascorbic acid as a standard. The results of the present study revealed that the acetone extract of leaves, stem and fruits can be a potential source of natural antioxidant, which can be applied as new source of Antioxidant Activity Index (AAI)which may complete demand of modern era to use such phytoconstituents or phytomedicines.

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Study of Glutathione Peroxidase GPX Activity Among Betel Quid Chewers of Indian Population

Study of Glutathione Peroxidase GPX Activity Among Betel Quid Chewers of Indian Population

Introduction Betel quid BQ chewing, a habit practiced in Eastern and North Eastern part of India, has known to be associated with cancer of the oral or buccal cavity. BQ is also one of the common mood elevating substances among Indian population. The BQ is a mixture of areca nut Areca catechu , catechu Acacia catechu and slaked lime calcium oxide and calcium hydroxide wrapped in a betel leaf Piper betel .BQ products have been classified by the International Agency for Research on Cancer IARC as group I human carcinogens . Glutathione peroxidise GPx , one of the major enzymatic antioxidant defence system, responsible for scavenging free radicals. Antioxidant enzymes catalyze decomposition of ROS. Overall balance between production and removal of ROS may be more important in various cancers including OSCC Oral squamous cell carcinoma or oral cancer. Methods In this study subjects were screened from Department of Oral and Maxillofacial surgery andE.N.T. of Ramakrishna Mission Seva Pratishthan Hospital RKMSP , Kolkata and different areas of West Bengal and North Eastern states of India. Quantitative in vitro determination of glutathione peroxidase activities in whole blood were estimated manually with 0.05 ml whole blood. The samples were assayed by UV Visible Spectrophotometer SPECORD 50 PLUS at a wavelength of 340nm. Results Most of the subjects had betel quid chewing habit. Glutathione peroxidase values are higher in healthy control than Cancer cases and Pre cancer with betel quid chewing habit, which is statistically significant. Conclusion Reactive oxygen species are generated due to slaked lime, one of the important constituents of betel quid which can modulate the oral pathology and promote carcinogenesis. Aniket Adhikari | Madhusnata De "Study of Glutathione Peroxidase (GPX) Activity Among Betel Quid Chewers of Indian Population" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd21619.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/21619/study-of-glutathione-peroxidase-gpx-activity-among-betel-quid-chewers-of-indian-population/aniket-adhikari

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