'Retrosynthetic analysis' presentation slideshows

Alkynes

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ERASMUS Intensive Program

ERASMUS Intensive Program. SYNAPS: Synthesis and Retrosynthesis in the Chemistry of Natural Products July 2011 NATURAL PRODUCT CHEMISTRY Module 2 Retrosynthetic Approaches Towards the Synthesis of Natural Products DEPARTMENT OF CHEMISTRY UNIVERSITY OF CRETE.

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Organic Synthesis

Organic Synthesis. A synthesis is a specific sequence of chemical reactions that converts starting materials into the desired compound, called the target of the synthesis (or the synthetic target ).

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Synthesis

Chapter 12. Synthesis. Suggested Problems -. 12.1 One-Step Syntheses. Solving one-step syntheses Analyze the structures of the reactant and product Assess HOW the functional groups have changed

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Chapter 15 & 16 Discussion

Chapter 15 & 16 Discussion. Synthesis problem. Retrosynthetic analysis (work backwards from product) Synthesis plan (Show forward reactions with reagents). Synthesis problem. Conjugation. How to prepare dienes ?. How to prepare dienes ?. Reactions of conjugated dienes.

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Total Synthesis of Isoschizogamine

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17.12 The Wittig Reaction

17.12 The Wittig Reaction. Some reactions of aldehydes and ketones progress beyond the nucleophilic addition stage. Acetal formation Imine formation Compounds related to imines Enamines The Wittig reaction.

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Discussion Amines

Discussion Amines. diisopropylamine. pyrrole. pyrrolidine. histamine. nicotine. Which is the strongest base?. Which is the weakest base?. lysine. Which is the most basic amino group in lysine? Why?. Which structure best represents lysine in living cells (physiological conditions).

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CHEMISTRY 4000

CHEMISTRY 4000. Topic #1: Introduction Fall 2012 Dr. Susan Findlay. Introduction to Retrosynthetic Analysis. Any synthesis of a specific target molecule must account for three main factors: Skeletal structure Functional groups Stereochemistry (relative and absolute).

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Rational Synthesis Design of a Potent Anti-Diabetic Therapeutic 'Pioglitazone' Using Retrosynthetic Analysis

Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drug research and development endeavor. The ability to design elegant and economical synthetic routes is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach, introduced and advanced by Prof. E. J. Corey of Harvard University has served as a powerful driving force on design elegant and economical synthetic routes to any useful molecule of scientific or industrial interest. Exploiting the advantages of this approach, we have proposed a good number of synthesis schemes for a potent anti-diabetic drug ‘Pioglitazone’.from the results of its retrosynthetic analysis. The proposed synthesis planning being a theoretical explorations, the actual laboratory execution requires a cross examination of so many factors such as reactions, reagents and order of events. The routes that utilize readily available starting materials, convergent, economical, safe and produce maximum yield in short reaction time are most feasible.

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Total Synthesis of Aplyviolene

Total Synthesis of Aplyviolene. M . J. Schnermann and L. E. Overman , J. Am. Chem. Soc. 2011 , 133 , 16425-16427. Total Synthesis of Aplyviolene. ] B. Sullivan and D. J. Faulkner, J. Org. Chem. 1984 , 49 , 3204-3206. Isolated from the marine sponge Dendrilla sp.

334 views • 9 slides