'Quantitative trait' presentation slideshows

MSc IAMZ - UAB - UPV 2007 - 2008

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Genetics for Epidemiologists Lecture 5: Analysis of Genetic Association Studies

Genetics for Epidemiologists Lecture 5: Analysis of Genetic Association Studies. National Human Genome Research Institute. U.S. Department of Health and Human Services National Institutes of Health National Human Genome Research Institute. National Institutes of Health.

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Genetics of Complex Traits and Diseases

Genetics of Complex Traits and Diseases. ??? zhangxianning@zju.edu.cn Tel? 13105819271; 88208367 Office: A705, Research Building 2012/09. Genetic Susceptibility ???.

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The Causes of Variation

The Causes of Variation. Lindon Eaves and Tim York Boulder, CO March 2001. One Issue (Among Many!). Identifying genes that cause complex diseases and genes that contribute to variation in quantitative traits. Quantitative Trait Locus (QTL).

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Hunting for Genes with Longitudinal Phenotype Data Using Stata Stata Conference Boston 2010 July 15, 2010

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Reverse genetics: Quantitative Trait Locus (QTL) mapping Association mapping

Reverse genetics: Quantitative Trait Locus (QTL) mapping Association mapping. Integrating Mendelian and Quantitative Genetics using molecular techniques. Allele A2. Allele A1. 12. 11. 22. 22. 11. 22. 12. 11. 22. 12. Quantitative trait. 16. 28. 40. 52. 64. 76. 88. Height.

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Genetics for Epidemiologists Study Designs: Family-based Studies

Genetics for Epidemiologists Study Designs: Family-based Studies. Thomas A. Pearson, MD, PhD University of Rochester School of Medicine Visiting Scientist, NHGRI. Genetics for Epidemiologists: Study Designs: Family-based Studies. Learning Objectives

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Linkage Analysis: An Introduction

Linkage Analysis: An Introduction. Pak Sham Twin Workshop 2001. Linkage Mapping. Compares inheritance pattern of trait with the inheritance pattern of chromosomal regions First gene-mapping in 1913 (Sturtevant) Uses naturally occurring DNA variation (polymorphisms) as genetic markers

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Linkage Analysis: An Introduction

Linkage Analysis: An Introduction. Pak Sham Twin Workshop 2001. Linkage Mapping. Compares inheritance pattern of trait with the inheritance pattern of chromosomal regions First gene-mapping in 1913 (Sturtevant) Uses naturally occurring DNA variation (polymorphisms) as genetic markers

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what is the goal of QTL study?

Dimension Reduction for Mapping mRNA Abundance as Quantitative Traits Brian S. Yandell University of Wisconsin-Madison www.stat.wisc.edu/~yandell/statgen [Lan et al. 2003 Genetics 164 (4): August 2003]. what is the goal of QTL study?. uncover underlying biochemistry

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Alcohol and genetics: Is your child at risk?

Alcohol and genetics: Is your child at risk?.

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15 The Genetic Basis of Complex Inheritance

15 The Genetic Basis of Complex Inheritance. Multifactorial Traits. Multifactorial traits are determined by multiple genetic and environmental factors acting together Multifactorial = complex traits = quantitative traits

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what is a QTL? what is the goal of your QTL study? why worry about multiple QTL?

QTLs & Microarrays Overview Brian S. Yandell University of Wisconsin-Madison www.stat.wisc.edu/~yandell/statgen. what is a QTL? what is the goal of your QTL study? why worry about multiple QTL? why study multiple traits together?. what is a QTL?. QTL = quantitative trait locus (or loci)

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Quantitative Genetics

Quantitative Genetics. Quantitative Traits. Mendel worked with traits that were all discrete, either/or traits: yellow or green, round or wrinkled, etc. Different alleles gave clearly distinguishable phenotypes.

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Regulation of gene expression in the mammalian eye and its relevance to eye disease

Regulation of gene expression in the mammalian eye and its relevance to eye disease. Todd Scheetz et al. Presented by John MC Ma. Aims. To determine loci related to genes expressed in rat eye by expression quantitative trait loci (eQTL)

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Quantitative Genetics

Quantitative Genetics. Quantitative Traits. Mendel worked with traits that were all discrete, either/or traits: yellow or green, round or wrinkled, etc. Different alleles gave clearly distinguishable phenotypes.

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MARKER ASSISTED SELECTION

MARKER ASSISTED SELECTION. Individuals carrying the trait of interest are selected based on a marker which is linked to the trait and not on the trait itself. Indirect selection. Useful when the trait is difficult to measure, and/or is evident only at late developmental stages. Winter.

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Response to Selection

Response to Selection. Bio 508: Evolution Robert Page Slides Courtesy of Dr. Voss. Heritability. h 2 = V A /V p. Proportion of total phenotypic variance attributable to additive genetic variance . Describes the extent to which offspring resemble their parents.

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