protein carbohydrate
Carbohydrates are involved in many important signaling pathways, and carbohydrate recognition is a key component of many biological processes including innate immunity, metabolism, and immune response. For example, glycans located on cell surfaces or secreted biomolecules play a crucial role in cellu2013cell interaction, including the interaction between host cell and pathogens. The physiological and pathological significance of glycanu2013protein interactions are drawing increasing attention in the field of structure-based drug design. However, it has been notoriously difficult to study these interactions by X-ray crystallography since the sugar moieties usually have a heterogeneous chemical structure and conformation. Computational molecular modeling techniques offer an attractive alternative method for the study of protein-carbohydrate recognition and specificity.
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