'Pls da' presentation slideshows

Integrative Analysis of High Dimensional Gene Expression, Metabolite and Blood Chemistry Data

Integrative Analysis of High Dimensional Gene Expression, Metabolite and Blood Chemistry Data. Kwan R. Lee, Ph.D. and Lei A. Zhu, Amit Bhattacharyya, J. Alan Menius Biomedical Data Sciences GlaxoSmithKline kwan.lee@gsk.com. Overview. Systems Biology Challenges for Statisticians

462 views • 45 slides

Gas composition from Biomass Torrefaction

157 views • 1 slides

PLS-DA

Partial least squares discriminant analysis (PLS-DA) is one of the most widely used classification techniques in chemo metrics. This approach has also been extensively used in u201comicsu201d related fields, such as metabolomics, proteomics, and genomics and in many other fields, which generates large amount of data such as spectroscopy, as described elsewhere. The increasing interest in PLS-DA method, especially in the field of metabolomics, is mainly due to its availability in most of the common statistical software packages.

26 views • 1 slides

OPLS-DA

Orthogonal partial least squares discriminant analysis (OPLS-DA) was introduced as an improvement of the PLS-DA approach to discriminate two or more groups (classes) using multivariate data. In OPLS-DA, a regression model is constructed between the multivariate data and a response variable that only contains class information. The obvious advantage of OPLS-DA compared with PLS-DA is that a single component serves as a predictor for the class, while the other components describe the variation orthogonal to the first predictive component. Wiklund et al. used the terms between treatment variation to depict the average effect of treatment and within treatment variation to describe the systematic remainder variation, which is not related to the treatment. The treatment effect is supposed to be equal for all subjects although the magnitude is allowed to be different for each subject. Treatment effects that differ from the average treatment effect are referred to as within treatment variation. Now, bioinformaticians at Creative Proteomics are proud to tell you we are open to help you with OPLS-DA Service!

27 views • 1 slides