'Pdgf' presentation slideshows

Perturbation of Signal Transduction

-. -. 1. 2. 1. 3. 2. 3. Perturbation of Signal Transduction Pathways for Growth Factors and Growth Inhibitors in Malignant Transformation. Ligand isoform. Extra- cellular. TM. Intra- cellular. Receptor type. Different isoforms of PDGF form three types of receptor dimers. PDGF-CC.

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PDGF ( c-sis of Simian Sarcoma)

PDGF ( c-sis of Simian Sarcoma). Dermatofibrosarcoma. Simian Sarcoma Virus (SSV). SSV- transforming retrovirus found in the wooly monkey Transforming gene- v-sis Homolog in humans- first deemed c-sis, located on chromosome 22

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PDGF- ? Receptor

PDGF- ? Receptor. Chris Halloran 03.04.2004. Baker, http://www.bcm.tmc.edu/medicine/hema-onco/lectures/mds/sld017.htm. PDGF- ? Receptor Function. Receptor Tyrosine Kinase Activated by PDGF ligand dimers. Lodish et al. Fig. 20-21. PDGFR Ligands. http://www.licr.org/07_spot/PDGF.htm.

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NEN_69_9_2010_06_29_CUI_200673_SDC3

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Wound healing assay MEFs wild type

Supplementary Figure 3. B. A. Wound healing assay MEFs wild type. Wound healing assay MEFs knock out. **. cells invading the artificial wound. cells invading the artificial wound. #. C PDGF. C PDGF SP. + PDGF.

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PDGF Family

Platelet-derived growth factor (PDGF) is one of numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells.

15 views • 1 slides