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Chapter 16 Notes

Chapter 16 Notes

Chapter 16 Notes. The Molecular Basis of Inheritance. Concept 16.1. Once Morgan showed that genes are located on chromosomes, DNA and proteins became the candidates for the genetic material.

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Lecture 24: Mutation and DNA repair

Lecture 24: Mutation and DNA repair

Lecture 24: Mutation and DNA repair. Announcements. Deamination of cytosine and adenine. Base analogs. Alkylating agents. Intercalating agents. UV-induced pyrimid ine dimers. High energy particles can damage DNA. Direct photoreactivation. Base excision repair.

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Announcements

Announcements

Announcements. Exam 3 is next Wednesday, 3/28 Material for Exam 3: Lectures 19-25 Topics: DNA replication, transcription, RNA processing, translation, cancer, DNA damage and DNA repair (assigned reading from Chaps. 11, 14, 15, 16) Key terms #7-8 Homeworks 5-7

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Repairing Damages Bases

Repairing Damages Bases

Repairing Damages Bases. 1. Mismatch repair (MMR). Dam methylase:. MutS:. Repairing Damages Bases. 1. Mismatch repair (MMR). Repairing Damages Bases. 2. Photoreactivation. Repairing Damages Bases. 3. Repair of alkylation. (BER). Repairing Damages Bases. 4. Base excision repair (BER).

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Transcription-Coupled Repair

Transcription-Coupled Repair

Transcription-Coupled Repair. nucleotide excision repair (NER). Nature, 411:366-374, 2001. Transcription-coupled repair. RNA polymerase II. NER machinery. sister chromatid. non-transcribed strand. transcription- blocking lesion. transcribed strand. TFIIH. CSB. CSA.

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