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Dysregulation of glutamate homeostasis in the NAc core

Dysregulation of glutamate homeostasis in the NAc core underlies relapse (Knackstedt et al., Biol. Psychiatry, 2009). Activation of mGlu2/3 receptors attenuates both stress and cue ethanol seeking (Zhao et al., J. Neurosci. 2006). Orthosteric ligands of mGlu receptors.

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Mglu receptors - PowerPoint PPT Presentation

Dysregulation of glutamate homeostasis in the NAc core