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Rett Syndrome

Rett Syndrome. Neurobiology of Disease. Rett Syndrome. 2nd most common genetic cause of Mental Retardation Early development normal ? loss of language, cognitive and motor abilities Single gene defect: Mecp2 KO (Jaenisch, Bird) recapitulates disease, as does forebrain neuron selective KO.

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Ko tudor et al - PowerPoint PPT Presentation

Rett Syndrome