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Protein-Protein Interactions and Inhibition of the ADP-Ribosyl Transferase Reaction of Pseudomonas aeruginosa Exotox

Protein-Protein Interactions and Inhibition of the ADP-Ribosyl Transferase Reaction of Pseudomonas aeruginosa Exotoxin A. Susan P. Yates Ph.D. Thesis Defence Supervisor: Dr. A. Rod Merrill. Outline. Background Research Objectives Inhibition of the catalytic domain of exotoxin A

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Lecture 16

Lecture 16. Inhibition Quiz on Friday, Oct. 14 (MM derivation (assume no E+P -> ES) and 6 enzyme classes-what types of reactions do they catalyze?). X. Y. X. Y. X. Y. Enzymes. Oxidoreductases: A - + B ? A + B - Transferases: A-B + C ? A + B-C Hydrolase: A-B + H 2 O ? A-H + B-OH

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Km increases - PowerPoint PPT Presentation

Protein-Protein Interactions and Inhibition of the ADP-Ribosyl Transferase Reaction of Pseudomonas aeruginosa Exotox

Lecture 16