'Haplotype' presentation slideshows

Haplotyping algorithms and structure of human variation

Haplotyping algorithms and structure of human variation. EECS 458 CWRU Fall 2004 Readings: see papers on the course website. Roadmap. Definition: haplotype and haplotype inference Why infer haplotypes Infer haplotypes from pedigree data Most probable haplotype configurations

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Haplotype analysis

Shaun Purcell shaun@pngu.mgh.harvard.edu MGH, Boston. Haplotype analysis. A a M aM m am This individual has aa and Mm genotypes and am and aM haplotypes . Haplotypes. A a M AM m Am This individual has AA and Mm genotypes

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Haplotype analysis

Shaun Purcell shaun@pngu.mgh.harvard.edu MGH, Boston. Haplotype analysis. A a M aM m am This individual has aa and Mm genotypes and am and aM haplotypes . Haplotypes. A a M AM m Am This individual has AA and Mm genotypes

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L6: Haplotype phasing

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Introduction to SNP and Haplotype Analysis

Introduction to SNP and Haplotype Analysis. Yao-Ting Huang. Kun-Mao Chao. Algorithms and Computational Biology Lab, Department of Computer Science & Information Engineering, National Taiwan University, Taiwan. Genetic Variations.

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Introduction to Haplotype Estimation

Introduction to Haplotype Estimation. Stat/Biostat 550. The Haplotype Problem. Suppose we genotype individuals at a number of tightly linked SNPs. A. C. G. C. C. T. T. T. G. C. G. C. G. A. A. C. C. C. C. C. A. G. G. C. The Haplotype Problem.

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HAPLOTYPE ANALYSIS

HAPLOTYPE ANALYSIS. Jing Hua Zhao MRC Epidemiology Unit Strangeways Research Laboratory Worts Causeway Cambridge CB1 8RN Comments sent to jinghua.zhao@mrc-epid.cam.ac.uk Copenhagen 3/2/2006. Outline. The rationale What? Why? How? Options for most groups Focus two aspects

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Combinatorial Algorithms for Maximum Likelihood Tag SNP Selection and Haplotype Inference

Combinatorial Algorithms for Maximum Likelihood Tag SNP Selection and Haplotype Inference. Ion Mandoiu University of Connecticut CS&E Department. Outline. Biological background Maximum likelihood tag SNP selection Maximum likelihood population haplotyping Ongoing and future work.

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Haplotype inference and haplotype-based transmission disequilibrium test (Hap-TDT)

?????????????? 2009 ?? . ???. Haplotype inference and haplotype-based transmission disequilibrium test (Hap-TDT). ??? ????????????. Outline. Haplotype inference Introduction of important methods Parsimony (Clark,1990) EM (Excoffier and Slatkin, 1995 )

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Haplotype ? ??? genetic linkage/ association ? ???? ???? ??

Haplotype ? ??? genetic linkage/ association ? ???? ???? ??. ??? 1) , ??? 2) , ??? 1) , ??? 3) , ??? 3) , ??? 3) , ??? 3) , ?? 1). 1) ????? ???? ?????? 2) ????? ?????? 3) ????? ??? ????. Background. Linkage Association

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Signatures of Selection

Signatures of Selection. Different types of selection leave behind different signatures on the genome. Negative selection : reduces variation at the affected site(s) but also at neighboring sites through background selection.

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Linear Reduction for Haplotype Inference

Linear Reduction for Haplotype Inference. Alex Zelikovsky joint work with Jingwu He. WABI 2004. Outline. SNP, haplotypes and genotypes Haplotype Inference Linear reduction method Improvements Experimental results Conclusions & future work. Human Genome and SNP.

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Linear Reduction Method for Tag SNPs Selection

Linear Reduction Method for Tag SNPs Selection. Jingwu He Alex Zelikovsky. Outline. SNPs , haplotypes and genotypes Haplotype tagging problem Linear reduction method for tagging Maximizing tagging separability Conclusions & future work. Outline.

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Allele group II

Rec OS3. Rec OS1. Rec OS2. A. B. F. B. Rec OS1. (-530 ~ -86). Allele group II. Rec OS2. (-530 ~ -86). E. G. C. U. Rec OS3. (-86 ~ +49). S. V. Substitution. W.

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A. Gene Structure of ' KCNJ2 '( 3759 ), Chr17

1) rs8066863 65,672,496. 2) rs9889883 65,675,555. 3) rs9897832 65,676,589. 4) rs993242 65,678,169. 5) rs236513 65,681,053. 6) rs1468472 65,682,344. 7) rs7221086 65,683,435. 8) rs173135 65,683,921. 9) rs9302914 65,684,617. 10) rs9302915 65,684,683.

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A. Gene Structure of ' SEPT4 '( 5414 ), Chr17 Minus Direction

1) rs3744109 53,949,196. 2) rs3744110 53,951,009. 3) rs1057068 53,953,438. 4) rs17741424 53,953,990. 5) rs8066773 53,956,551. 6) rs2079703 53,958,977. 7) rs16943080 53,959,482. 8) rs740605 53,959,810. 9) rs2072316 53,959,812. 10) rs11870671 53,960,359.

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The HAP webserver: Tools for the Discovery of Genetic Basis of Human Disease

The HAP webserver: Tools for the Discovery of Genetic Basis of Human Disease. HYUN MIN KANG Computer Science and Engineering University of California, San Diego. GRACE SHAW Computer Science and Engineering University of California, San Diego. NOAH ZAITLEN Bioinformatics Program

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A Adey et al. Nature 500 , 207-211 (2013) doi:10.1038/nature12064

Gene expression by copy number and haplotype in HeLa S3. A Adey et al. Nature 500 , 207-211 (2013) doi:10.1038/nature12064.

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M. sphinx northern cyt b haplotype

A. B. M. sphinx northern cyt b haplotype. M. sphinx southern cyt b haplotype. M. leucophaeus cyt b. C. SIVmnd2 primers. SIVdrl primers. D. SIV-Artis DFRKYTAFTIPSVNNQGPGIRYQYNVLPQGWKGSPAIFQATADKILQPFREKNPDVIIYQ YMDD LFVGSDRPKHLHDQMIKELRTHLRFWGLETPDKKFQDNPPYEWM

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Abstract

Short arm. Short arm. Short arm. Short arm. Long arm. Long arm. Long arm. Long arm. Applications of Homozygosity Haplotype in the Study of Human Genetic Diseases with High Density SNP Genotype Haiyan Jiang 1 ,Mark Samuels 1,2 ,Duane Guernsey 1 ,Andrew Orr 1,3

216 views • 1 slides