'Global alignments' presentation slideshows

Global alignments - PowerPoint PPT Presentation

Bio 101: Genomics & Computational Biology

Bio 101: Genomics & Computational Biology

Bio 101: Genomics & Computational Biology. Tue Sep 18 Intro 1: Computing, statistics, Perl, Mathematica Tue Sep 25 Intro 2: Biology, comparative genomics, models & evidence, applications Tue Oct 02 DNA 1: Polymorphisms, populations, statistics, pharmacogenomics, databases

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717 views • 54 slides
DNA1: Last week's take-home lessons

DNA1: Last week's take-home lessons

DNA1: Last week's take-home lessons. Types of mutants Mutation, drift, selection Binomial for each Association studies c 2 statistic Linked & causative alleles Alleles, Haplotypes, genotypes Computing the first genome, the second ... New technologies

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650 views • 53 slides
Alignments

Alignments

Alignments. Why do Alignments?. Detecting Selection. Evolution of Drug Resistance in HIV. Selection on Amino Acid Properties. TreeSAAP (2003) Wu Method ( Sainudiin et al. 2005 ). Alpha-helical tendencies Average number of surrounding residues Beta-structure tendencies Bulkiness

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426 views • 28 slides
Bioinformatics (4)

Bioinformatics (4)

Bioinformatics (4). Sequence Analysis. DNA2: the last 5000 generations. NA1: Common & simple. Sequence Similarity and Homology. figure. Alignments & Scores. Local (motif) ACCACACA :::: ACACCATA Score= 4(+1) = 4. Global (e.g. haplotype) ACCACACA ::xx::x: ACACCATA

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350 views • 25 slides
Introduction to Bioinformatics

Introduction to Bioinformatics

Introduction to Bioinformatics. Lecture 6 Substitution matrices. What to align, nucleotide or amino acid sequences?. If ORF then align at protein level (i) Many mutations within DNA are synonymous, leading to overestimation of sequence divergence if compared at the DNA level.

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360 views • 22 slides

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