'Genetic interactions' presentation slideshows

Functional Genomics

2.07k views • 112 slides

Systems Modelling in Cell Biology

Systems Modelling in Cell Biology. Brian Ingalls Applied Mathematics University of Waterloo Waterloo, Ontario, Canada bingalls@math.uwaterloo.ca. Outline. System modelling - focus on dynamics Model development Analysis: 1) Parametric Sensitivity Analysis

1.1k views • 89 slides

Synthetic Lethality

Synthetic Lethality. X. A. X. Viable!. Y. B. X. Viable!. Z. C. Product. Dead!. Inactivating two interacting pathways causes lethality (or sickness). A. A. a D. a D. X. X. B. B. b D. b D. Wild-type. Viable. Viable. Lethal. Synthetic Lethality.

1.14k views • 76 slides

Genecentric: Finding Graph Theoretic Structure in High-Throughput Epistasis Data

628 views • 62 slides

Dynamic multivariate phenotypes and genetic interactions

Dynamic multivariate phenotypes and genetic interactions. Joining Forces Day, ETH 20.11.2009 Wolfgang Huber EMBL Heidelberg. Complex traits. Do not follow Mendelian inheritance, result from multiple alleles Responsible alleles contribute different amounts to phenotype

528 views • 38 slides

Lecturer: Trey Ideker

Network Clustering Experimental network mapping Graph theory and terminology Scale-free architecture Integrating with gene essentiality Robustness. Lecturer: Trey Ideker. Measurements of molecular interactions. Protein-protein interactions Yeast-two-hybrid Kinase-substrate assays

513 views • 35 slides

Lecturer: Trey Ideker

Network Clustering Experimental network mapping Graph theory and terminology Scale-free architecture Integrating with gene essentiality Robustness. Lecturer: Trey Ideker. Measurements of molecular interactions. Protein-protein interactions Yeast-two-hybrid Kinase-substrate assays

434 views • 35 slides

array of plenty - results from a 4 base resolution yeast genome tiling array

array of plenty - results from a 4 base resolution yeast genome tiling array. Wolfgang Huber European Molecular Biology Laboratory EBI. Bioinformatics and Computational Biology Solutions Using R and Bioconductor, R. Gentleman, V. Carey, W. Huber, R. Irizarry, S. Dudoit. Springer (Aug. 2005).

503 views • 34 slides

Pathway Association Analysis Trey Ideker UCSD

Pathway Association Analysis Trey Ideker UCSD. A working network map of the cell. Network evolutionary comparison / cross-species alignment to identify conserved modules. Network-based classification of cases vs. controls. The Working Map.

469 views • 33 slides

Estimating genetic interactions from combinatorial RNAi screens

Estimating genetic interactions from combinatorial RNAi screens. IASC Yokohama 7 December 2008 Wolfgang Huber European Molecular Biology Laboratory European Bioinformatics Institute. Many genes are functionally uncharacterized. Homo sapiens 25,000 Drosophila 15,000 C. elegans 17,000

407 views • 30 slides

Mapping signaling networks through genetic interaction analysis by RNAi

433 views • 28 slides

Joint analysis of genetic and physical interactions in S. cerevisiae

419 views • 28 slides

Functional Information from Genetic Interactions

Functional Information from Genetic Interactions . Bernd Fischer. Genome Wide Association Studies. Currently ~400 variants that contribute to common traits and diseases are known Individual and the cumulative effects are disappointingly small

377 views • 27 slides

EMBL Systems Microscopy Meeting

EMBL Systems Microscopy Meeting. Bernd Fischer. rhdf5. R-package rhdf5 will appear tonight on http://www.bioconductor.org Easy to install on all platforms (windows, linux, MacOS) No need to install additional hdf5 libraries Ability to read (and write) HDF5 files from cellcognition in R.

374 views • 24 slides

Functional Information from Genetic Interactions

Functional Information from Genetic Interactions . Bernd Fischer. Genome Wide Association Studies. Currently ~400 variants that contribute to common traits and diseases are known Individual and the cumulative effects are disappointingly small

333 views • 23 slides

Breach the Dams

Breach the Dams. Erica Digby Clay Callow Heath Korell. http://photoblog.msnbc.msn.com/_news/2011/10/26/8500522-hole-blasted-in-condit-dam-to-restore-endangered-fish-habitat. Background .

380 views • 22 slides

EMBL Systems Microscopy Meeting

EMBL Systems Microscopy Meeting. Bernd Fischer. Definition of Genetic Interactions. Design of Combinatorial knock-down Screen. 1367 x 72 Drosophila genes each targeted by two independent dsRNA designs 1456 plates (=559.104 wells) ~100.000 distinct gene pairs. Imaging.

284 views • 19 slides

Modeling cells with protein networks

285 views • 17 slides

Improving Curation Efficiency: User Contributions and Textpresso-Based Semi-Automation

Improving Curation Efficiency: User Contributions and Textpresso-Based Semi-Automation. WormBase Literature Curators Textpresso. SAB 2008. How does data get into WormBase?. Institution: Sanger Institute SUBMITTED FROM PAGE: http://www.wormbase.org/db/seq/gbrowse /elegans/

247 views • 15 slides

193 views • 5 slides