'Ectopic expression' presentation slideshows

Analysis of gene function Loss-of-function Many gene knock-out have no obvious phenotypes

Analysis of gene function Loss-of-function Many gene knock-out have no obvious phenotypes Redundancy? No perfect redundancy => subtle phenotype Gain-of-function Many give observable phenotypes (e.g. oncogenes) mis-expression enhanced expression ectopic expression

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Witzel et al. J Cell Biol . (2006)

Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel et al. J Cell Biol . (2006). Vertebrate Noncanonical Wnt Signaling. PCP signaling play key roles in cell polarization and migration during gastrulation.

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HCVM

HCVM. Member of b -herpesvirus family >200 ORFs Genes are expressed in a regulated cascade Some fulfill regulatory functions pUL38 expression during early phase pUL38 blocks apoptosis. http://www.abbottdiagnostics.co.uk. Tuberous Sclerosis Complex. Autosomal dominant disorder

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Transcriptional Specificity of Dysfusion

Transcriptional Specificity of Dysfusion. Dys Forms a Heterodimer with Tgo In Vivo. Ectopic Dys Expression cause ectopic Tgo nuclear Localization. Dys::Tgo Activates TCGTG, GCGTG and ACGTG in S2 Cell Culture. Nxf::Arnt and Nxf::Tgo Activates TCGTG,GCGTG and ACGTG. Trh:Tgo Activates ACGTG.

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Point mutations in a distant sonic hedgehog cis -regulator generate a variable regulatory

Point mutations in a distant sonic hedgehog cis -regulator generate a variable regulatory output responsible for preaxial polydactyly Laura A. Lettice , Alison E. Hill, Paul S. Devenney and Robert E. Hill. Polydactyly.

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Fusion cell gene profiling

Identify dys fusion cell enhancer. Fusion cell gene profiling. dys-gal4::UAS-CD8-GFP. btl-gal4::UAS-CD8-GFP. Identify dys target gene. dys-gal4::UAS-CD8-GFP. dys-gal4::UAS-CD8-GFP ; dys/dys. Molecular mechanism of target gene regulation by Dys::Tgo. Dys::Tgo activation of CG13196.

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Supplementary Figure S6. Effects of OHT and ectopic expression of FOXM1 and ER? in the

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