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Bcr abl hypothesis - PowerPoint PPT Presentation

POSSIBLE MECHANISMS OF IMATINIB RESISTANCE

Formal evidence in patients still pending. POSSIBLE MECHANISMS OF IMATINIB RESISTANCE . BCR/ABL gene dependent Point mutations at catalytic site of BCR/ABL gene BCR/ABL gene amplification BCR/ABL gene up-regulation BCR/ABL gene independent Increase of protein binding

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Bcr abl hypothesis - PowerPoint PPT Presentation

POSSIBLE MECHANISMS OF IMATINIB RESISTANCE