'Antitumor activity' presentation slideshows

Aporphine alkaloids

Aporphine alkaloids. All the aporphine alkaloids are based on the 4H-dibenzo quinoline structure or its 3-methyl derivative commonly known as the aporphine nucleus. The numbering system is as indicated, so as to conform with the "Ring Index". Glaucine.

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GDC-0449: From Corn Lilies to a Cure BCCNS Symposium September 19.2009

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Bleomycin

Bleomycin. ???? ??????? ??? ????????? ???? 92/4/31. ??????? ?????? ????? ?????: ?.????. Taxanes. paclitaxel and docetaxel exert their cytotoxic effect by interfering with microtubule function . ( Pizzo 2011, p:325).

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1 Vall d'Hebron University Hospital, Barcelona, Spain

A Phase 2 Multicenter Study Evaluating the Efficacy and Safety of IMC-11F8, a Recombinant Human IgG 1 Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody (MAb), Combined With 5-FU/FA and Oxaliplatin (mFOLFOX-6) as First-Line Therapy in Patients With Advanced Colorectal Cancer (CRC).

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Synthesis, molecular docking studies and cytotoxic screening of certain novel thiazolidinone derivatives substituted wit

Substituted thiazolidinone linked to benzothiazoles and benzoxazoles 3a,b or substituted 5-benzylidene-4- thiazolidinones 4a-h were synthesized. The antitumor activity of the prepared compounds was evaluated against human breast MCF7 and liver HEPG2 cancer cell lines using Sulphorhodamine-B (SRB) assay method, doxorubicin was used as a reference standard. Most of the tested compounds showed potent antitumor activity especially the pmethoxy-5-benzylidine-4-thiazolidinone derivative of benzoxazole 4c and benzothiazole 4d, their IC50 against liver HEPG2 cancer cell line are 0.027 nM and 0.026 nM respectively. The IC50 of p-chloro-5-benzylidine-4- thiazolidinone linked to benzoxazole 4e against breast MCF7 cancer cell line, is 19 nM but, p-nitro-5-benzylidine4-thiazolidinone derivative of benzothiazole 4h showed a broad spectrum antitumor activity against MCF7 and HEPG2 cell lines, its IC50 is 36 and 48 nM respectively. The most active compounds were docked against VEGFR-2 using Moe program and 1Y6A (pdb file) to investigate if these compounds had a similar binding mode to VEGFR-2 inhibitors.

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Center for Direct Catalytic Conversion of Biomass to Biofuels

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Abstract (Updated)

oxaliplatin 85 mg/m 2 IV infusion. IMC-11F8 800 mg (absolute dose) IV infusion. 5-FU 400 mg/m 2 bolus infusion. 5-FU 2400 mg/m 2 continuous infusion. Rest. FA 400 mg/m 2 IV infusion. 1 hour. 2-4 minutes. 46 hours. 50 minutes. 2 hours.

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Samir M. El-Moghazy, Nahed M. Eid, Sahar M. Abou-Seri and Shaimaa M. Abdel-Rahman *

SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF NEW 5-FURANOISOXAZOLINE AND 5-FURANOPYRAZOLINE DERIVATIVES. Samir M. El-Moghazy, Nahed M. Eid, Sahar M. Abou-Seri and Shaimaa M. Abdel-Rahman * Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University.

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MAK683

tMAK683 is an inhibitor of embryonic ectoderm development protein (EED) with potential antineoplastic activity. MAK683 binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), leading to a conformational change in the EED H3K27me3-binding pocket and preventing the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2). MAK683 is undergoing phase II clinical trials for the identification of antitumor activity.

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