'Amyloid precursor protein' presentation slideshows

CASE PRESENTATION

CASE PRESENTATION. Dr. LU, QINCHI DEPARTMENT OF NEUROLOGY REN JI HOSPITAL SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE Tel: 58752345-3094 Email: qinchilu@hotmail.com. History.

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Epigenesis:

Epigenesis:. Synonyms: Gene Expression, Gene Regulation. Definition: Anything genetic above and beyond the sequence of nucleotides. Importance: Everything , especially development and genetic responses to the environment. Examples of Epigenesis:.

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???? ???. ?????? ???????. ?????? ????????? ????? ?? ????? ??? ????? - ????? ???? (???????) ???? ?????? ? ??? ????. Multiple diseases, Nutrition, Finance, Compliance. Aging. Decline in Organ System Functions: Glomerular Filtration Cardiac Index Breathing Capacity. Aging.

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Faghihi, MA et al . Nature Medicine 2008 Presenter: Chen-Chung Lin

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Chapter 3:The Chemical Building Blocks of Life

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Cell Biology of Human Diseases

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ALZHEIMER'S DISEASE (AD)

ALZHEIMER'S DISEASE (AD). Senile dementia. Characterised by amyloid plaques + tau protein ~ 600,000 cases in UK 5% hereditary; 95% spontaneous Frequent in Down's syndrome (extra chromosome 21). AD - PLAQUES. From St George-Hyslop (2000). PLAQUES b -amyloid ( b A)

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regulatory subunit

SAH. SAM. regulatory subunit. CH3. B. B. Methyltransferase. A. C. A. C. A. C. Active PP2A. Inactive PP2A. SAH. P-tau. Tau. ATP. Kinases. ADP. +. Presenilin 1. ? -amyloid. Amyloid precursor protein. Secretases overexpression. +. HCY. DNA-hypomethylation. Accumulates

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