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Aml1 eto - PowerPoint PPT Presentation

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1.35k views • 105 slides

Molecular Pathogenesis of Leukemia

Type I mutations. Type II mutations. Mutations that affect proliferation/survival. Mutations that impair differentiation. BCR-ABL. PML/RAR a. PDGFR b. PLZF/RAR a, etc. AML1/ETO CBF b /SMMHC TEL/AML1 Other transloc. Flt3 ITD or mutation. C-KIT mutation. MLL translocations.

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714 views • 44 slides

Figure S1

Figure S1. A. HSPC-AE. pMSCV. HA. AML1-ETO. IRES. GFP. AE. HSPC-control. +. +. -. -. AE fl/fl. -. -. +. +. Cre-YFP. -. +. -. +. AE fl/fl. YFP. +. -. +. -. pMSCV. IRES. GFP. Cre-YFP. YFP. HA-AML1-ETO. Tubulin. loxP. AML1-ETO. IRES. GFP. loxP. B. C.

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Aml1 eto - PowerPoint PPT Presentation

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Molecular Pathogenesis of Leukemia

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