'Akt' presentation slideshows

AKT

485 views • 30 slides

Abstract #3503

Abstract #3503. A Phase I Study of MK-2206, an Oral Potent Allosteric Akt Inhibitor in Patients with Advanced Solid Tumors.

386 views • 24 slides

Abstract #3503

Abstract #3503. A Phase I Study of MK-2206, an Oral Potent Allosteric Akt Inhibitor in Patients with Advanced Solid Tumors.

330 views • 24 slides

Journal Club

Journal Club. Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ . Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012 Oct 16;157(8): 549-57. ?????????????????????????

359 views • 21 slides

DIFFERENTIAL EFFECTS OF (LENTI)VIRUS INFECTION ON AKT SIGNALLING IN CD4+ T CELLS

DIFFERENTIAL EFFECTS OF (LENTI)VIRUS INFECTION ON AKT SIGNALLING IN CD4+ T CELLS. Pavel Bostik FMHS Charles University Medical School University Hospital Hradec Kralove Czech Republic. ORIGIN OF HIV. Cercocebus atys SIVsm. Pan troglodytes) SIVcpz. Macacca mulat a. HIV-2.

348 views • 17 slides

Calpain 2 regulation of Akt in glioblastoma cell invasion

Calpain 2 regulation of Akt in glioblastoma cell invasion. Presented by Maria Nguyen Guidance of Dr. Jeffrey A. Greenwood. Glioblastoma is highly invasive. Less than 5% chance of survival over 5 year span. Pre-surgery. Post-surgery. 12 months. 17 months. Glioblastoma.

415 views • 16 slides

ST2 Teaching Programme 2014-15

242 views • 14 slides

AKT Postgraduates Colloquium Planning Meeting

252 views • 11 slides

AKT Postgraduates Colloquium Planning Meeting

222 views • 11 slides

Developing Strategy for Next Generation of Antibody - Drug Conjugates

Comprised of a recombination monoclonal antibody and cytotoxic payloads through a linker, antibody drug conjugate (ADC) not only has highly cytotoxic antitumor effect of small molecule drugs, but also combines the high selectivity, stability and favorable pharmacokinetic characteristics of mAb.

120 views • 10 slides

Akt inhibitor

Also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds. Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family.

120 views • 10 slides

AL4

A. B. Supplimental figure 1. Melanoma free survival curve (A) and summary table (B) for median survival and melanoma free survival for each genotype. All of them are Ink/Arf-/-. C. A. B. EV. Sh4. Sh11. PTEN. AL4. ECAD. NCAD. pAKT. pERK. EV. Sh4. Sh11. -. pFAK. Pten. pSTAT.

264 views • 4 slides

Figure S1

Figure S1. A. B. C. Figure S2. A. B. Antagonism. Synergism. Additivity. Figure S3. Bright-field. Annexin V. PI. merge. DMSO. MLN0128. TSA. MLN0128/TSA. Figure S4. SKBR3. 25. 25. 25. 0. 0. 0. INK128 ( nM ). n o treatment. 0. 1000. 50. TSA ( nM ). pAKT S473.

122 views • 4 slides

cGMP??????????????-2???????

cGMP??????????????-2???????.

106 views • 2 slides

Supplementary Figure S2

Supplementary Figure S2. Rapamycin induction of p-AKT occurs within 1 hour and is not due to increased levels of p- Src. A. BT474. MCF7. MDA-MB-231. p-AKT. t-AKT. p- Src. t- Src. p-S6. t-S6. ? -act. B. MCF7. BT474. MDA-MB-231. p-AKT. t -AKT. p- Src. t- Src.

124 views • 1 slides

p-Akt Ser(473)

JVM-2. Jeko-1. C P E. C P E. p-Akt Ser(473). Akt.

83 views • 1 slides

14-3-3 ?

P-Akt. 14-3-3 ?. Control siRNA. 14-3-3 ? siRNA. Neal et al.Supplementary Figure S1. a. b. Control siRNA. 14-3-3 ? siRNA. C1 C2 si1 si2 si3. P-Akt. Akt. 14-3-3 ?. c. d. Control siRNA. 14-3-3 ? siRNA. Control shRNA. 14-3-3 ? shRNA1. 14-3-3 ? shRNA2. 0.

186 views • 1 slides

Suppl Figure 5

Suppl Figure 5. MB947. MB1337. MB1547. Immunoblot of Effector Proteins in Tumors from PDTX Mice Treated with TAK-733. TAK-733. vehicle. S6. vehicle. vehicle. TAK-733. TAK-733. pS6. AKT. pAKT. ERK. pERK 1/2. ?-tubulin. S. TGI Response. R. S. WT. BRAF Status. V600E. V600E.

103 views • 1 slides

PI3K-AKT Signaling Pathway

PI3K-AKT Signaling Pathway:?http://www.creative-diagnostics.com/PI3K-AKT-Signaling-Pathway.htm

124 views • 1 slides

akt pathway

PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Key proteins involved are phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B.

50 views • 1 slides