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What is a fragment?

What is a fragment?. Advantages?. Size of chemical space: 10 7 or 10 60 ?. Disadvantages?. No of compounds to screen. Chance of finding a hit (complexity). Drug-like compounds (rule of 5). lead-like compounds (rule of 3). Ligand efficiency, LE. FBDD. Group efficiency, LE.

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350 da - PowerPoint PPT Presentation

What is a fragment?