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Luke the Limping Labrador

Luke the Limping Labrador. Linden Craig, DVM, PhD, DACVP. Signalment. 10 year old Intact male Black Labrador retriever. Clinical History. One year duration Swelling and lameness Left stifle. Luke at UT. Painful swollen stifle FNA – viscous fluid. UT Radiographs. Biopsy. Diagnosis?.

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Luke the Limping Labrador

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  1. Luke the Limping Labrador Linden Craig, DVM, PhD, DACVP Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  2. Signalment • 10 year old • Intact male • Black Labrador retriever Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  3. Clinical History • One year duration • Swelling and lameness • Left stifle Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. Luke at UT • Painful swollen stifle • FNA – viscous fluid Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  5. UT Radiographs Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  6. Biopsy Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Diagnosis? Synovial myxoma Benign, slow growing Nodular morphology Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Synovial Myxoma 1. Adult Doberman – stifle synovectomy  curative 2. 16 yr old Doberman – stifle amputation  curative 3. 9 yr old English spaniel – C2 & C3 incidental finding at necropsy Tumors in Domestic Animals 4th ed, DJ Meuten Ed, 2002, p. 213 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  9. Synovial Myxoma • Labrador retriever – tarsus • Miniature poodle – stifle • Doberman cross – carpus • Doberman cross – stifle • Doberman – carpus • Doberman – stifle doxorubicin  died The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Luke’s Leg Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. 07-3354 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Synovial Myxoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  14. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  15. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  16. Invasion into bone Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  17. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  18. Synovium Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  19. Secrete synovial fluid Dendritic cells Synoviocytes + Type C synoviocyte Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  20. Synoviocytes H&E Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only CD18

  21. Synoviocytes  tumors(Craig Hypothesis) • Type A – Dendritic cell • Histiocytic sarcoma • Type B – Secretes synovial fluid • Synovial myxoma • Type C – Transitional or stem cell • Synovial cell sarcoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  22. Synovial Tumors - Survival The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  23. Synovial Myxoma Summary • Slow growing • Nodular • Benign Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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