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NIH Roadmap Initiative From Bench to Bedside

“It is the responsibility of those of us involved in today’s biomedical research enterprise to translate the remarkable scientific innovations we are witnessing into health gains for the nation”. NIH Roadmap Initiative From Bench to Bedside. Elias Zerhouni, MD Director, NIH NEJM 2005.

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NIH Roadmap Initiative From Bench to Bedside

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  1. “It is the responsibility of those of us involved in today’s biomedical research enterprise to translate the remarkable scientific innovations we are witnessing into health gains for the nation” NIH Roadmap Initiative From Bench to Bedside Elias Zerhouni, MD Director, NIH NEJM 2005

  2. NIH roadmap initiatives • New pathways to discovery (bench science) • New approaches to unravel the complexities of biologic systems (proteomics, metabolomics, new tools/probes) • Research teams of the future (bedside science) • Promotion of interdisciplinary research and training • Removing barriers to interdisciplinary research • Promoting public-private sector liaisons • Re-engineering the clinical research enterprise • Creation of research networks • Clinical research workforce training • Translational research; “bench to bedside” teams

  3. Key Functions of the CTSA • CTSA serve to concentrate basic, translational and clinical investigators, community clinicians, clinical practices, networks, professional societies and industry • Establish innovative clinical/translational research • Bridging of clinical and basic scientists • Expansion of biomedical informatics • Biostatistics, research ethics programs • Community engagement • Education and training (MS or PhD) • Establish communications with other centers and industry

  4. Impact of CTSA’s • Funding for GCRC’s will be phased out over next 3-5 years. • Functions of GCRC will be included in CTSA • Lack of Institutional Commitment will impact applicant institutions • No ‘home’; no award • Will require interdisciplinary interaction • Academic and clinical silos will need to integrate • Will require closer collaboration between basic, translational, and clinical scientists • Lack of an Institutional CTSA will impact future applications to NIH

  5. Following the Roadmap • Step 1: • Institutional Clinical and Translational Science Award (CTSA; RFA; U54 mechanism) • Direct application for full award • Planning application • Due March 27, 2006 (and yearly thereafter) • Full awards • $30 million available for FY 2006 • Up to $6 million in total costs for 5 years • 4-7 awards for FY 2006 for full award • Planning awards • $11.5 million available for FY 2006 • 50 awards for FY 2006

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