Figure 1
This presentation is the property of its rightful owner.
Sponsored Links
1 / 8

41.7 PowerPoint PPT Presentation


  • 64 Views
  • Uploaded on
  • Presentation posted in: General

Figure 1. Age distribution of tested dogs. 45. 41.7. 40. 35. 30. Percent. 25. 20. 15.6. 15. 12.5. 9.4. 10. 6.3. 4.2. 4.2. 4.2. 5. 2.1. 0. <=1. 1-2. 2-3. 3-4. 4-5. 5-6. 6-7. 7-8. >8. Age (years). Figure 2. Expected proportions of false negatives and false positives.

Download Presentation

41.7

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


41 7

Figure 1

Age distribution of tested dogs

45

41.7

40

35

30

Percent

25

20

15.6

15

12.5

9.4

10

6.3

4.2

4.2

4.2

5

2.1

0

<=1

1-2

2-3

3-4

4-5

5-6

6-7

7-8

>8

Age (years)


41 7

Figure 2

Expected proportions of false negatives and false positives

6.0

4.0

5.5

3.5

5.0

3.0

ICH–specificity = 87 %

4.5

2.5

CDV & ICH-sensitivity = 95 %

Proportion of false positives (%)

Specificity

Sensitivity

Sensitivity

Proportion of false negatives (%)

4.0

2.0

3.5

1.5

3.0

1.0

2.5

0.5

CPV-sensitivity = 97 %

2.0

0.0

75

80

85

90

95

100

True prevalence of protected dogs (%)


41 7

Figure 3

Distribution of scores for the level of immunity (N = 322 dogs)

60

60

60

a)

b)

c)

55

55

55

Protected

50

50

50

No

45

45

45

Yes

40

40

40

35

35

35

Percent

30

30

30

25

25

25

20

20

20

15

15

15

10

10

10

5

5

5

0

0

0

Score

0

1

2

3

4

5

6

0

1

2

3

4

5

6

0

1

2

3

4

5

6

Canine Parvovirus

Canine Distemper Virus

Infectious Canine Hepatitis


41 7

Figure 4

Comparison of scores in the first and the second test (N = 74 dogs)

80

80

80

a)

b)

c)

75

75

75

Tests

70

70

70

First

65

65

65

60

60

60

Second

55

55

55

50

50

50

Score<3 in 2nd test: 8.1 %

Score<3 in 2nd test: 6.8 %

Score<3 in 2nd test: 18.9 %

45

45

45

40

40

40

Percent

35

35

35

30

30

30

25

25

25

20

20

20

15

15

15

10

10

10

5

5

5

0

0

0

Test

1

2

1

2

1

2

1

2

1

2

1

2

1

2

1

2

1

2

1

2

1

2

1

2

Score

3

4

5

6

3

4

5

6

3

4

5

6

Canine Parvovirus

Canine Distemper Virus

Infectious Canine Hepatitis


41 7

Figure 5

Difference in scores between first and second test (2nd – 1th)

60

60

60

a)

b)

c)

55

55

55

Scores

50

50

50

Lower in 2nd test

45

45

45

Unchanged

40

40

40

Higher in 2nd test

35

35

35

Percent

30

30

30

25

25

25

20

20

20

15

15

15

10

10

10

5

5

5

0

0

0

Diff.

-4

-3

-2

-1

0

1

2

-4

-3

-2

-1

0

1

2

-4

-3

-2

-1

0

1

2

Canine Parvovirus

Canine Distemper Virus

Infectious Canine Hepatitis


41 7

Figure 6

Relationships between difference in scores between 1th and 2nd test (2nd – 1th)

4

4

4

a)

b)

c)

3

3

3

1

4

2

1

1

1

1

2

2

2

1

4

3

7

2

3

1

1

1

1

1

2

6

22

1

7

13

1

2

2

11

4

2

0

0

0

CDV Difference (2nd – 1th)

ICH Difference (2nd – 1th)

ICH Difference (2nd – 1th)

1

2

4

12

1

1

6

14

2

1

6

13

1

2

-1

-1

-1

1

3

1

2

2

2

7

1

6

3

2

1

-2

-2

-2

1

1

1

2

1

1

1

1

1

1

3

-3

-3

-3

1

2

1

1

-4

-4

-4

-4

-3

-2

-1

0

1

2

3

4

-4

-3

-2

-1

0

1

2

3

4

-4

-3

-2

-1

0

1

2

3

4

CPV Difference (2nd – 1th)

CPV Difference (2nd – 1th)

CDV Difference (2nd – 1th)


41 7

Figure 7

Predicted probability of test score < 3 as a function of age

0.25

0.20

Maximum Likelihood Estimates

CPV: α = - 0.40 (p = 0.001); β = - 1.18 (p < 0.001)

0.15

CDV: α = - 0.19 (p = 0.025); β = - 1.48 (p < 0.001)

ICH: α = - 0.26 (p = 0.002); β = - 1.12 (p < 0.001)

Predicted probability

0.10

0.05

0.00

0

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Age (years)


41 7

Figure 8

Estimated true prevalence of unprotected dogs as a function of age

25

20

Legend

Specificity+Pr(T+)-100

p = 100 -

CPV

Sensitivity+Specificity-100

15

CDV

p = Estim. True prev. of unprotected

Pr(T+) = Prop. tested protected

Estimated true prevalence (%)

ICH

10

5

0

0

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Age (years)


  • Login