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Laxative

Laxative. Dean Chen June 4, 2008. Type of laxative. Bulk-producing agents Stool softeners / Surfactants Lubricants / Emollient Stimulant / Irritant Saline (consider a hydrating agent). Types (continue). Hydrating agents (osmotics) One more :Hyperosmotic agents

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Laxative

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  1. Laxative Dean Chen June 4, 2008

  2. Type of laxative • Bulk-producing agents • Stool softeners / Surfactants • Lubricants / Emollient • Stimulant / Irritant • Saline (consider a hydrating agent)

  3. Types (continue) Hydrating agents (osmotics) • One more :Hyperosmotic agents • Some Vegetable also consider laxatives

  4. Stool softeners / Surfactants • Site of Action: Small and large intestine • Onset of Action: 12 - 72 hours • Examples: docustate (Colace, Diocto) • Stool softeners help mix fluid into stools to soften them. This makes stools easier to pass out of the body.

  5. colace Colace Stool Softener Laxative Capsules 50 Mg - 30 Each Active ingredient Docusate Sodium (50 mg). Dosage form: Capsules List Price $11.56

  6. Colace (cont) • Colace is used for prevention of dry, hard stools. • DIRECTIONS: Adults and children 12 years and older: 1 to 4 capsules Children 6 to 12 years old: 1 to 2 capsules • PRECAUTION: The highest dose should be taken until the first bowel movement; thereafter, a lower dose should be taken for maintenance. The effect of Colace on the stools may not be apparent until 1 to 3 days after the first oral dose.

  7. Hyperosmotic agents • Site of Action: Colon • Onset of Action: 0.5 - 3 hours • Examples: Glycerinsuppositories, Sorbitol, Lactulose, and Polyethylene glycol (PEG). • PEG found more effective in children than lactulose

  8. Miralax MiraLAX Laxative Powder 7-Day - 4.1 oz (119 g) Active ingredient Polyethylene Glycol 3350, 17 g (cap filled to line). Dosage form is powder List Price $8.35

  9. Miralax • Use for bowel movement and constipation • Fill up to the white line (17g) on the cup Stir and dissolve in 4 to 8 oz of liquid Use once a day • Children under 16 years of age please consult a doctor before taking it. • Do not take more than indicated

  10. Bulk-producing agents • Site of Action: Small and large intestine • Onset of Action: 12 - 72 hours • Examples: psyllium husk (Metamucil), methylcellulose (Citrucel), polycarbophil, dietary fiber • How it work: The larger stools help trigger the bowel to contract and move the stools out. You must use this daily to be effective

  11. Metamucil (psyllium ) Metamucil Apple Crisp Natural Fiber Wafers - 24 • The Dosage form is a wafer • Active Ingredient isPsyllium husk • List Price $6.11

  12. Metamucil (cont) • Use: for daily instake of fiber and gentle elimination w/0 chemical • Adult should take 2 wafers with 8 oz of their faveorite beverage. Child 6 to 12 take 1 wafer with beverage • Warning: choking and Allergy alart; should consult doctor before taking it

  13. Stimulant / Irritant • Site of Action: Colon • Onset of Action: 15min to 8 hours depending the drug • Example: Senokot , Dulcolax Bowel prep kit • Stimulant laxatives are the harshest laxatives. They cause the bowel to squeeze or contract to move the stools out

  14. Senokot (senna) • Senokot Tablets - 20 Each • Active ingredientEach tablet contains: Purified Senna (8.6 mg). • Dosage form is tablet • List Price $7.81

  15. Senokot (cont) • Use:Senokot tablets generally produce bowel movement in 6 to 12 hours. • Adult take 2 times a day Children under 6 1 tablet a day. It is reommended taking at bedtime • Should not use for more than 1 week and should not be taken with GI problems. If bowel movement persist for more than 2 weeks consult your doctor

  16. Saline • Site of Action: Small and large intestine • Onset of Action: 0.5 - 6 hours • Saline laxatives draw fluid into the bowel from nearby tissue. This softens stools and helps the bowel move them out.

  17. Milk of Magnesia • Phillips Milk Of Magnesia Liquid Cherry - 26 Oz • Liquid dosage form: liquid • Active ingredient: Teaspoon (5 mL): Magnesium Hydroxide 400 mg. • List Price $10.14

  18. Milk of Magnesia (cont) • use: To relieve occasional constipation • Adults/Children 12 years and older: 2-4 tablespoonful (TBSP) . Children: Children 6-11 years: 1-2 tablespoonsful, .2-5 years: 1-3 teaspoonsful, all age group followed by a full glass (8 oz.) of liquid Take at bedtime or upon rising. • Precaution: Consult doctor before taking. Should not be use for more than 1 week and should top taking if GI or allergy problem

  19. Lubricants / Emollient • Site of Action: Colon • Onset of Action: 6 - 8 hours • Example : Glycerin Suppositories, mineral oil • Lubricant laxatives work by coating the surface of the stools. This helps the stools hold in water so they move out of the body more easily

  20. conclusion • Contact me at dfc0102@yahoo.com • You can access the links and the dcoument at my web site www.deanchen.com

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