First Annual Meeting

1. First Annual Meeting

2. Indiana CTSI HUB: A Unique Resource William Barnett, Ph.D., Indiana University

3. Presentation Overview • Introduction to the Indiana CTSI HUB • Overview of HUB technologies • Discussion of Indiana CTSI HUB accomplishments

4. Unique features of the Indiana CTSI call for a robust online resource • A collaboration between IU and Purdue • Extensive expertise in bioinformatics and medical research, engineering research, and medical informatics. The IU School of Medicine is one of the largest schools of medicine in the country in terms of number of trainees • A statewide translational medicine initiative that includes universities, hospitals, industry, practitioners, and the public • Many of our constituents, spread hundreds of miles apart, are connected by a high speed network, I-LIGHT

5. The vision for the Indiana CTSI HUB • Implies a locus of collaboration and services that is efficient, easy to use, and meets constituency needs A central portal through which all translational activities flow

6. ~ $1 million/year for development NSF Network for Computational Nanotechnology The I-CTSI has adopted Purdue’s web-based Virtual Organization HUB platform 2002 1995 2008 2012 HUBzero Community Source Software Consortium Mark Lundstrom Purdue University …others

7. Example: NanoHUB • Designed for engineers in the nanotech community • Supports user contributed resources and presentations • Specialized online simulation tools can be embedded using an innovative browser embedded virtual environment

8. NanoHUB Usage 85,000 users worldwide • 7,000,000 hits/month • All Top 50 US Engr Schools • 14% of all .edu domains • 333 International Ed Institutions • 233 US K-12 schools

9. Physical Machine Maxwell’s Daemon Middleware Virtual Machine Violin HUBs are based on Purdue’s HUBzero platform and Web 2.0 standards LAMP Architecture: Web Server • Add new capabilities through… • PHP components • Simulation tools

10. Key Features of HUB frameworks • Extensible – anyone can create and contribute new applications and access distributed resources (such as computational grids) • Open - Fully compliant with Web 2.0 standards provides flexibility • Trustworthy – IP management and citation system structures contributions • Collaborative – Social networking and group-based sharing features • Interactive – tools for online tutorials, podcasts, simulations, and analysis • Evaluative - user ranking and feedback, and trouble ticketing • Descriptive - Semantic tagging infrastructure for resource description

11. I-CTSI HUB service model • Service-aligned: to be a statewide cyberinfrastructure that provides community defined trusted services • Partnership-based: to develop novel services and find service gaps, leveraging work done by other organizations • Priority-driven: to focus on the institutional priorities and encourage adoption by meeting constituency needs

12. First Year Indiana CTSI HUB Accomplishments • Integrated Search • Grant Proposal Management • Community Health Outreach • Online TTR Services • Identity Management Infrastructure

13. Integrated Search of Distributed Resources • To discover resources at the Indiana CTSI and beyond • Some of our data are standalone, some federated, making easy search solutions hard. • Developed an easy to use search that searches our clinical trials, faculty publications, PubMed (using NCBI services), people, web pages and resources. Results are separated in easy to use drop down boxes on a single page

14. Grant Proposal Management Service • An online platform to advertise internal grant programs, provide application materials and forms, submit proposals, assign and notify reviewers, collect reviews, document decisions, and notify applicants • Based Open Journal System software, a web-based open source journal/publication peer-review management system. Adapted to manage proposals instead of publications • First RFA received 104 proposals (previous average was 30). Now being adopted by other units.

15. Community and Health Engagement Program • To build active partnerships with community advocacy groups • Quickly built a MySQL database of community organizations and forms for them to individually manage organizational information and provide feedback to CHEP • Community groups are key partners in clinical trials recruitment, education, and data for population health studies through partners such as the Polis Center.

16. TTR Intercampus Utilization Project • The Intercampus TTR utilization structure is developing a framework to support Financial, Legal and IP, and Logistics for seamless intercampus TTR service utilization • The Indiana CTSI Core scope covers IU Bloomington, IUPUI, IUSM, Notre Dame, and Purdue core facilities and services • The TTR Program aspires to serve pre-clinical and clinical research as well as provide analytical resources for the growing Indiana life sciences industry • The goal is to have a single, competitive, online e-commerce marketplace of TTR services for Indiana life sciences and health care

17. Identity Management • Began by accommodating university identity management systems (LDAP and CAS) at IU, Purdue, and Notre Dame • Indiana CTSI is now the first CTSA to be a member of the InCommon Federation and accept InCommon authentication • Moving to InCommon application authentication, based on Shibboleth • Researching COmanage tools for managing group permissions to resources across multiple institutions using InCommon credentials

18. Thanks to a dedicated team • CTSI Administration: Judy King, Lilith Reeves, Emily Hardwick, Samantha Scahill • Purdue University: Mike McLennan, Charles Buck, Mike Beyerlein, Shawn Rice, Nick Kissenberth, Steve Snyder • BioEthics: Jere Odell • Library/Knowledge Informatics: Julie McGowan, Beth Whipple, Elaine Skopelja • Bioinformatics Core: Sean Mooney, Peter Baenziger, Craig Sanders • BioStatistics Core: Robert Davis, Ganesh Shankar • IUSM Cancer Center: Damon Clements • UITS Advanced IT Core: Bill Barnett (Chair), Anurag Shankar, Michael Grobe

19. Thank youhttp://www.indianactsi.org/ Bill Barnett (Indiana U.) barnettw@iu.edu