David A. Steenblock, M.S., D.O . and Donna Hanna, ND Personalized Regenerative Medicine TM Mission Viejo, California. The Causes and Treatments of Spontaneous ALS. 26381 Crown Valley Pkwy, St. 130, Mission Viejo, Calif, USA; 800-300-1063. Amyotrophic Lateral Sclerosis.
The Causes and Treatments
of Spontaneous ALS
26381 Crown Valley Pkwy, St. 130, Mission Viejo, Calif, USA; 800-300-1063
My “wholistic” approach has been
1. Damage to spinal nerves releases toxic cytokines including
2. The spinal nerve damage opens the spinal CSF-blood barrier which allows toxins to enter the CSF and spinal cord.
Menozzi A, Ossiprandi MC. Assessment of enteral bacteria. CurrProtocToxicol 2010, Chapter 21: Unit 21.3.
Toxic microbials Neurodegeneration, Cell 2010; 140: 918-934.
into the GI tract
Flowing into the bloodstream
Wijesekera LC, Leigh PN. Amyotrophic lateral sclerosis. Orphanet J Rare Dis 2009; Feb 3; 4:3.
Strickland D, et al. Physical activity, trauma, and ALS: a case-control study. Acta Neurol Scand 1996; 94(1):45-50.
Fan ZK, et al. The effect of aminoguanidine on compression spinal cord injury in rats. Brain Res 2010, 25;1342:1-10.
Degenerative conditions that have impinged the spinal arteries can lead to marginal oxygenation in the spinal cord.
Schneeweis C, et al. Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration. J AtherosclerThromb 2010; 17(2):203-12.
A test for Nocturnal Oximetry
is recommended for ALS patients.
help to reduce free radical stress in the spine.
de Carvalho M, et al. Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis: periodic desaturation. Amyotroph Lateral Scler 2009; 10(3): 154-61.
The following is a list of environmental risk factors for ALS that may interact with genetic factors:
Xu L, et al. Oxidative stress in immune-mediated motoneuron destruction. Brain Res 2009; 1302: 225-32.
Endotoxins = Lipopolysaccharides
Li B, et al. The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury. Brain Res 2008; 1226: 199-208.
Frakes AE., et al. Microglia induce motor neuron death via the classical
NF-kB pathway in amyotrophic lateral sclerosis. Neurons 2014; 81(5): 1009-23.
Tolosa L, et al. TNF-a potentiates glutamate-induced spinal cord motoneuron death via NF-κB. Mol Cell Neurosci 2011; 46(1): 176-86.
Miyazaki K, et al. Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis. J Neurosci Res 2011; 89(5):718-28.
MMP-9 is activated by:
Kaplan A et al. Neuronal matrix metalloproteinase-9 as a determinant of selective neurodegeneration. Neuron 2014; 81(2): 333-48.
Factors that promote inflammation in the GI tract include:
Doctor’s Data has the following tests. If one laboratory does the tests, it’s easier to compare results from one patient to the next as well as utilize for research purposes.
(to determine what “bad” bugs are present in the gut).
Roos PM, et al. Metal concentrations in cerebrospinal fluid and blood plasma from patients with amyotrophic lateral sclerosis. Biol Trace Elem Res 2013; 151(2): 159-70.
Junas-Morales R, et al. Environmental factors in ALS. Presse Med 2014; 43(5): 549-54.
Nervous system deterioration
Depletes glutathione peroxidase, binds to thiol groups
Induces mitochondrial dysfunction, reduces
ATP synthesis, increases DNA damage
Hearing, speech, vision and gait impairment
Causes involuntary muscle movements
Disrupts endocrine gland function
Causes difficulty with chewing and swallowing
negative bacteria which deposit
fragments of their outer cell wall (endotoxins=lipopolysaccharides)
into the gut wall.
Longstreth WT Jr, et al. Hypothesis: a motor neuron toxin produced by clostridial species residing in gut causes ALS. Med Hypoth 2005; 64(6): 1153-6.
Clostridia infection in the GI tract
Other Clostridium species include:
Bugs in the system.The Economist. 3 November 2012.
Jang SE, et al. Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages. IntImmuno-pharmacol 2014; 21(1): 186-92.
Smits HH, et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells. J Allergy ClinImmunol 2005; 115(6): 1260-7.
Yeast and fungal overgrowth markers include:
Malabsorption and Bacterial Markers include:
(Creosote is a dirt mixture of polycyclic aromatic hydrocarbons that also includes clostridia.)
Jing F, et al. Metabolic Kinetics of 5-Hydroxytryptamine. Dig Dis Sci 2014, Jun 12 [Epub ahead of print]
Dupuis L et al. Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. PLoS One 2010; 5(10):e13346.
Sandyk R. Serotonergic mechanisms in amyotrophic lateral sclerosis. Int J Neurosci 2006; 116(7): 775-826.
large amounts of tumor necrosis
factor alpha that inhibit glutamate
transport in astrocytes and cause
excitation in synapses (through
Calcium ion/AMPA receptors)
that then release excess glutamate.
Olmos G, et al. Tumor necrosis factor alpha: a link between neuro- inflammation and excitotoxicity. Mediators Inflamm 2014; 2014: 861231.
For ALS patients, taking 100mg, 3 times a day of
5-hydroxytryptophan (serotonin) is recommended.
1. lemon balm,
3. Resveratrol, and
Hawkes WC and Alkan Z. Regulation of Redox Signaling by Selenoproteins. Biol Trace Elem Res 2010; 134: 235-251.
Llzecka J, et al. Matrix metalloproteinase-9 (MMP-9) activity in cerebrospinal fluid of amyotrophic lateral sclerosis patients.
Communication in the
Kanouchi T, et al. Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation? J Neurol Neurosurg Psychiatry 2012; 83(7):739-45.
Biasini E, et al. A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci 2013; 33(6): 2408-18.
Monocytes are white blood cells (leukocytes).
Before coming to our clinic:
After sufficient detoxification, hyperbaric oxygen therapy
Pronto-Laborinho AC, et al. Roles of VEGF in ALS. Biomed Res Int 2014; 2014: 947513.
(Magonate) – take up to point of diarrhea and then decrease dosage.
Get magnesium cream and rub into the muscles at least once a day.
2 capsules, 3 times per day.
If the patient will be in the sun for 30 plus minutes, take 20 capsules orally 3 hours beforehand and try to get the abdomen exposed to the sun as much possible. Don’t use sunblock. Allow the sun to kill off some of the monocytes.
The following can be mixed together and added to green fresh drinks:
If faciculations (muscle twitching) are present, add:
Give 1-2 ml per day subcutaneously. Watch for red colored urine – when you see this within 1-2 hours of getting the shot, you are getting enough, so stay on that dose everyday. The more of this, the more nerve regeneration occurs.
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