Lupine crooked calf disease
This presentation is the property of its rightful owner.
Sponsored Links
1 / 7

Lupine- “Crooked Calf Disease” PowerPoint PPT Presentation


  • 52 Views
  • Uploaded on
  • Presentation posted in: General

Lupine- “Crooked Calf Disease”. Can it be related to birth defects in other species?. Case Problem Overview. Lupine caused significant calf losses in the Western United States (4,000+ calves from 12,000 cows died in one county) New human baby born in mountainous backcountry of NW California

Download Presentation

Lupine- “Crooked Calf Disease”

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Lupine crooked calf disease

Lupine- “Crooked Calf Disease”

Can it be related to birth defects in other species?


Case problem overview

Case Problem Overview

  • Lupine caused significant calf losses in the Western United States (4,000+ calves from 12,000 cows died in one county)

  • New human baby born in mountainous backcountry of NW California

    • severe bone deformities in arms and hands

    • partial absence of forearm bones

    • absence of thumbs

    • medical history indicates deformities were not the result of genetics

  • Goats on the farm gave birth to deformed kids

  • Pregnant bitch was fed goat’s milk and had a litter of deformed puppies

  • Pregnant woman also drank goat’s milk during pregnancy


What is crooked calf disease

What is Crooked Calf Disease?

  • characterized by bone abnormalities in the forelimbs, spine, and skull

  • can be directly attributed to a pregnant mother’s ingestion of a specific lupine alkaloid, anagyrine

  • the alkaloids act as a sedative, keeping the fetus in an abnormal position, so that it continues to grow while fixed in that position. this causes the bone abnormalities.3


Hypothesis

Hypothesis

  • We hypothesize that there is a relation between the birth defects of the human baby, goats, and dogs to the lupine induced “crooked calf disease”.

    • symptoms are similar

  • Goats grazing may have ingested the lupine alkaloid, which allowed the toxin in their system

    • it seems to be transmittable through milk

    • evidenced by the fact that both the woman and bitch drank the goat’s milk and had deformed offspring


Evidence to support hypothesis

Evidence to support Hypothesis

  • Lupine ingestion is widely accepted as the cause of “crooked calf disease”

  • No direct evidence available between lupine and goats

  • Tests could be run to detect the presence of anagyrine in goat’s milk

    • it has been found that when goats are fed lupine seeds, anagyrine can be detected in the milk almost immediately.2

    • Investigations in test animals to determine how much of the anagyrine needs to be transferred to cause abnormalities


Conclusions

Conclusions

  • Circumstances are too coincidental to be three separate, isolated incidents

  • appears to support hypothesis


References

References

  • 1.http://www.wisc.edu/ansci_repro/lab/lab12_03/lab12_cases/case7_goat.htm

  • 2. Kilgore, Wendell W., Crosby, Donald G.,  Craigmill, Arthur L., and Poppen, Norman K. <http://extoxnet.orst.edu/newsletters/n23_81.htm>

  • 3. <http://www.vetmed.wsu.edu/depts-fdiu/CrookCalf.asp>


  • Login