Is there a link between inflammatory bowel disease and the metabolic syndrome
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Is there a link between inflammatory bowel disease and the metabolic syndrome?. Hester Franks Academic F2 Supervisors Professors Hawkey and Macdonald. Background and hypothesis Methods Results to date. Background and hypothesis. Inflammatory bowel disease (IBD) Crohn’s disease (CD)

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Is there a link between inflammatory bowel disease and the metabolic syndrome l.jpg

Is there a link between inflammatory bowel disease and the metabolic syndrome?

Hester Franks

Academic F2

Supervisors Professors Hawkey and Macdonald


Slide2 l.jpg


Background and hypothesis l.jpg
Background and hypothesis metabolic syndrome?

  • Inflammatory bowel disease (IBD)

    • Crohn’s disease (CD)

    • Ulcerative colitis (UC)

  • Metabolic syndrome

  • Genetic predisposition to both conditions

  • There seem to be an increasing number of obese patients in IBD clinics.

  • Is it possible that in the obese patients it is their obesity/the metabolic syndrome rather than these polymorphisms which predisposes them to IBD?


Methods l.jpg
Methods metabolic syndrome?

  • 3 groups

    • CD BMI>28

    • CD BMI<23

    • Controls BMI>28

  • 2 parts to study

    • Genetic analysis for SNPs & baseline metabolic analysis

    • Detailed analysis of fasting and postprandial metabolic state


Results l.jpg
Results metabolic syndrome?

  • So far

    • 167 UC patients

    • 110 CD patients

  • Healthy volunteers being recruited by advertisement

  • No gene/metabolic data yet


Bmi distributions of uc and cd l.jpg
BMI distributions of UC and CD metabolic syndrome?


Conclusions to date l.jpg
Conclusions to date metabolic syndrome?

  • There does seem to be an overweight subgroup in CD +/- UC

  • SNP analysis may give us evidence that some of the overweight patients have IBD as a manifestation of the metabolic syndrome


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