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Is there a link between inflammatory bowel disease and the metabolic syndrome?. Hester Franks Academic F2 Supervisors Professors Hawkey and Macdonald. Background and hypothesis Methods Results to date. Background and hypothesis. Inflammatory bowel disease (IBD) Crohn’s disease (CD)

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Is there a link between inflammatory bowel disease and the metabolic syndrome?

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Is there a link between inflammatory bowel disease and the metabolic syndrome l.jpg

Is there a link between inflammatory bowel disease and the metabolic syndrome?

Hester Franks

Academic F2

Supervisors Professors Hawkey and Macdonald


Slide2 l.jpg

  • Background and hypothesis

  • Methods

  • Results to date


Background and hypothesis l.jpg

Background and hypothesis

  • Inflammatory bowel disease (IBD)

    • Crohn’s disease (CD)

    • Ulcerative colitis (UC)

  • Metabolic syndrome

  • Genetic predisposition to both conditions

  • There seem to be an increasing number of obese patients in IBD clinics.

  • Is it possible that in the obese patients it is their obesity/the metabolic syndrome rather than these polymorphisms which predisposes them to IBD?


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Methods

  • 3 groups

    • CD BMI>28

    • CD BMI<23

    • Controls BMI>28

  • 2 parts to study

    • Genetic analysis for SNPs & baseline metabolic analysis

    • Detailed analysis of fasting and postprandial metabolic state


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Results

  • So far

    • 167 UC patients

    • 110 CD patients

  • Healthy volunteers being recruited by advertisement

  • No gene/metabolic data yet


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BMI distributions of UC and CD


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Conclusions to date

  • There does seem to be an overweight subgroup in CD +/- UC

  • SNP analysis may give us evidence that some of the overweight patients have IBD as a manifestation of the metabolic syndrome


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