Supplementary Figure 1: Definition of retinoid resistance by morphology, and TALE family gene expres...
This presentation is the property of its rightful owner.
Sponsored Links
1 / 2

LAN6 PowerPoint PPT Presentation


  • 80 Views
  • Uploaded on
  • Presentation posted in: General

Download Presentation

LAN6

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Lan6

Supplementary Figure 1: Definition of retinoid resistance by morphology, and TALE family gene expression response to RA. A) Prototypical RA-sensitive and RA-resistant NB cell lines, treated with DMSO and 13-cisRA. The cell lines LAN-6 and CHLA90 are RA-sensitive cell lines, with smaller cell bodies and some neurite formation in complete media under control conditions (DMSO); when treated with 13-cisRA, proliferation slows and long neuritic processes develop extending from the cell bodies. In contrast, the RA-resistant cells CHLA15 and SK-N-AS have flatter and larger cell bodies under control conditions and no neurite formation or significant apoptosis when treated with 13-cisRA. B) Expression of TALE gene family members other than PBX1 do not correlate with treatment with 13-cisRA. The relative mRNA expression of PBX2, PBX3, PBX4 (top row), MEIS1, MEIS2, MEIS3 (middle row), and PKNOX1 and PKNOX2 in 4 RA-resistant cell lines (blue bars) and 11 RA-sensitive cell lines (red bars), as measured by RT-qPCR.

A

LAN6

CHLA90

CHLA15

SK-N-RA

DMSO

13-cis RA


Supplementary figure 1b see legend above

Supplementary Figure 1B (see legend above)

PBX2

PBX3

PBX4

MEIS1

MEIS2

MEIS3

PKNOX2

PKNOX1


  • Login