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Diabetes or high blood sugar today has become as common issue in every family life.<br>Without even realizing we can manage diabetes, if we accept it easily.<br>There is a phase between our normal blood sugar and prediabetes. So, during prediabetes if we start medications along with diet management and increase level of activity, we can really delay any complications for 30 to 40 years.<br>Whenever we think of diabetes, kidney failure and insulin are two factors.<br>Kidney failure is not the only thing. We can become blind or have heart attack.<br>We can lose sensations in our feet leading to amputation of our legs.<br>Everybody knows diabetes because it is so common, every drug company is making medicines and now there are 13 groups of excellent medications available and together they can really keep us very healthy.<br>Last but not the least, we really have to connect with our doctor and a dietitian and seek counseling.<br>You will feel good, healthy & have no symptoms for long and will be very tempting not to take any medications but it is going to cost money too, especially in India.<br>If you want to ignore the reality, it is not going to go away.
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Metformin – The most common and famous prescribed medicine Add15years.com Add15years.in Author: (Prof.)Dr.S.OmGoel,MD/DM From family ofdoctors from AIIMS, MAMC & Delhi University MD Medicine,USA DM/Fellowship,USA
Metformin – The most common and famous prescribed medicine • Metformin (1,1-dimethylbiguanide), a biguanide derivate and its chemical structure is related to guanidine. • Insulin sensitizer • Most widely prescribed drug to treat hyperglycemia, at least 120 million user worldwide. • Monotherapy & in combination with all antidiabetic. www.add15years.com www.add15years.in
History • Metformin was first prepared in 1922 by the Dublin chemists • Jean sternewasthe first to try metformin on humans for the treatment of diabetes. • He coined the name “Glucophage” for the drug and published his results in 1957. • Metformin was introduced to the United Kingdom in 1958, France in 1957, and Canada in 1972. www.add15years.com www.add15years.in
Popular Brands • Glucophage • Metformin Hydrochloride ER • Glumetza • Rioment • Fortamet • Glucophage XR • Diamin • Formin • Met – 500 • Bigomet www.add15years.com www.add15years.in
Mechanism of action Decrease hepatic glucose production through a mild inhibitions of the mitochondrial respiratory-chain. Decrease intestinal absorption of glucose. Anti-oxidative properties of metformin on endothelial cells www.add15years.com www.add15years.in
Actions of metformin • Anti-obesity effects: • Decreased appetite • Increased GLP-1 sections • Anti-hyperglycemic effects: • Decreased intestinal carbohydrate absorption • Inhibition of hepatic gluconeogenesis • Enhancement of insulin-stimulated glucose transport in the skeletal muscle. www.add15years.com www.add15years.in
Side Effect • Metallic taste in the mouth • Gastrointestinal (anorexia, cough, vomiting, abdominal discomfort) • Vitamin B12 deficiency • Lactic acidosis • Reduce appetite • Fatigue www.add15years.com www.add15years.in
AVAIL OFFERNOW ADD100RsOFF ADD100%OFF Author: (Prof.)Dr.S.OmGoel,MD/DM From family ofdoctors fromAIIMS,MAMC &DelhiUniversity MD Medicine,USA DM/Fellowship,USA www.add15years.comwww.add15years.in
