MZDZ. DSNR. DSDZ. DZNR. MZNR. MZDS. MZ. DS. DZ. NR. Left. Left. Right. Right. MZ. DS. DZ. 1. 3. 6. 10. Subjects and image data. Subjects : Image data provided by D. Weinberger, NIMH, Bethesda : MZ : 10 healthy monozygotic twin pairs (N=2*10)
Subjects and image data
Lateralized change of ventricular shape in monozygotic twins discordant for schizophrenia
2M Styner, 1,2G Gerig, 3DW Jones, 3DR Weinberger,
Dept. of 1Psychiatry and 2Computer Science
University of North Carolina, Chapel Hill,
NC 27614, USA
3 National Institute of Health, Bethesda, MD
[email protected] / http://www.cs.unc.edu/~gerig
Llateral ventricle shapes after volume normalization. Ventricles of 10 DS twin pairs (left) and 5 MZ and 5 DZ pairs (right) are shown side by side.
Enlarged ventricular size and/or asymmetry have been found markers for psychiatric illness, including schizophrenia. We studied ventricular size and shape in volumetric MRI (N=2*30) of dizygotic twin pairs (DZ, N=2*10), monozygotic normal twin pairs (MZ, N=2*10), and monozygotic twin pairs discordant for schizophrenia (DS, N=2*10). Left and right ventricles were segmented from high resolution T1 SPGR MRI using automatic, atlas-based voxel labeling and 3D connectivity analysis. Surfaces of segmented lateral ventricles were parametrized using spherical harmonics (SPHARM) and spatially aligned based on the intrinsic coordinate frame of a coarse-scale shape description. Pairwise shape difference was measured as the mean squared distance (MSD) between corresponding surface points. Statistical analysis for group differences between normal MZ, discordant MZ (DS) and DZ using both, absolute volumes and relative volume difference within twin pairs, was not significant. Shape analysis within pairs, after scaling for individual volumes, revealed a strong shape similarity for left and right ventricles in normal MZ but also discordant DS pairs, which was significantly different from DZ pairs. DS pairs showed very small shape differences very similar to MZ, suggesting no change due to disease and strong pairwise shape similarity due to genetics. Our results indicate that shape analysis based on individual surface parameterization is a very sensitive technique to study subtle shape alterations.
Relative ventricle volume differences between twin pairs (|T1-T2|/(T1+T2)) for the MZ, DS, DZ and NR groups. Mean difference tests were not significant between all the groups.
Absolute volumes (top) and pairwise correlation of ventricle volumes (right).
Global Shape Analysis
Group differences of pairwise shape similarity (p-values)
Ventricle shape differences between twin pairs for MZ, DS, DZ and NR groups. Shape difference metric: Mean square difference (MSD) between object surfaces.
Quantitative morphologic assessment of individual brain structures inneuroimaging most often includes segmentation followed by volumemeasurements. Volumes and volume changes are intuitive features as they might explain atrophy or dilation of structures due to illness. On the other hand, subtle, well localized structural changes are not sufficiently reflected in global volume measurements. Development of new methods for three-dimensional shape analysis aims at tackling this issue and promises better sensitivity to subtle deformations. Shape analysis applied to twin studies offers the possibility to systematically study shape variability, both in healthy subjects and subjects discordant for disease, w.r.t. genetic difference.
Locality: Average of local twin pair shape difference
The T1w high resolution MR image data are processed by automatic brain tissue segmentation followed by shape parameterization.
Locality: Local group tests of pairwise differences
 A. Kelemen, G. Székely, and G. Gerig, „Three-dimensional Model-based Segmentation“, IEEE Transactions on Medical Imaging (IEEE TMI), 18(10):828-839, Oct 1999
 A. Bartley, D. Jones, and D. Weinberger, “Genetic variability of human brain size and cortical patterns”,Brain, vol. 120, pp. 257–269, 1997.
 G. Gerig, M. Styner, D. Jones, D. Weinberger, and J. Lieberman, “Shape Analysis of brain ventricles using SPHARM”, in: Proc. Workshop on Math. Methods in Biomed. Image Analysis MMBIA 2001, IEEE Comp Soc, pp. 171-178, Dec. 2001
Hierarchical surface parameterization by SPHARM
Parameterized object surfaces showing correspondences.