Hygiene hypothesis and allergic pathologies. “another problem with having money”. Introduction- What is the Hygiene Hypothesis.
Hygiene hypothesis and allergic pathologies.
“another problem with having money”
of microbial. Ag
(LPS, CpG, lipoteichoic a.)
dendritic c., macrophage,
intensive, long term
weak, short term
antibodies production, isotypic switching
IMMUNOREGULATORY SUBSETS OF T CELLS
- mature T cells (TH0) differentiate into functionally distinct
subsets after antigen stimulation
immunopathological reaction Ist type
Expansion of theory.
Helminthic therapy, a type of immunotherapy, is the
treatment of autoimmune diseases and immune
disorders by means of deliberate infestation with a
helminth or with the ova of a helminth. Helminths are
parasitic worms such as hookworms and whipworms.
“The Hygiene Hypothesis originated with earlier experiments with animals, mainly mice and rats born and raised in "germ-free" or sterile environments. When experimentally exposed to low doses of an infectious agent that would not harm normally raised rodents, these germ-free adolescent and young adult animals became infected quickly and often died”
Medicine.net Charles P. Davis, MD, PhD
“Sardinians are an isolated, inbred group, and they have experienced a twin epidemic of multiple sclerosis and type I diabetes, both autoimmune diseases, in the past sixty years—ever since they got rid of malaria. For the past few thousand years, those Sardinians that were genetically resistant to the malaria parasite survived; those that were not did not. The relentless presence of malaria in their environment shaped their genomes.”
Velasquez-Manoff- An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases