Diphenhydramine. Banan Muneer Laboum Wala ’ Fayez Sabateen. Pharmacology. Antihistamine with anti cholinergic properties Antitussive, anti emetic and local anesthetic properties. Antihistaminic (H1)property Relief itching and irritation caused by :
Wala’ Fayez Sabateen
Antihistamine with anti cholinergic properties
Antitussive, anti emetic and local anesthetic properties
Plant induced dermatitis
Animal serum antivenoms or anti toxin
drug-induced extrapyramidal symptoms
Maximal effects are at 1 hour after IV injection and lasts up to 7 hours
Serum half-life is 3-7 hours
Pruritus caused by poison oak , poison ivy or minor insect bites
Pretreatment before administration of animal serum antivenoms or antitoxins, esp. in patients with a history of hypersensitivity or with positive skin test
Scombroid – contaminated fish ingestion
Rapid IV administration of
Eg. of these drugs :
Haloperidol, Phenothiazines, Clozapine
Alteration in the normal balance between central acetylcholine and dopamine transmission
Blocks dopamine receptors in CTZ
Sensitizes tissues to acetylcholine
Prostatic hypertrophy with obstructive uropathy
Angel- closure glaucoma
Concurrent therapy with MAOI
Some preparations may contain sulfite preservatives allergic-type reactions in susceptible persons.
-- 25-50 mg PO q. 4-6 hrs, max. daily dose is 300 mg.
-- 6.25 mg q. 4-6 hrs, max. daily dose is 37.5 mg
12.5 to 25 mg PO q. 4-6 hrs, max. daily dose 150mg.
Children: 0.5-1 mg/kg IV
Children, 0.5-1 mg/kg
Repeat dose to a maximum 100 mg (adults).
Maxi. daily dose 400 mg.
The suggested minimum stocking level to treat a 70-kg adult for the first 24 hours is: