Top Ten Tips for Success

1. Top Ten Tips for Success Continuous Glucose Monitoring

2. 1 Sensor Insertion 60  • Ensure the Sensor is placed snugly into the SenSerter so that the o-rings are NOT visible • The angle of Sensor insertion is crucial for appropriate Sensor penetration depth and “wetting” • Insert the Sensor at a minimum of 60° by gently tilting the SenSerter forward 

3. 2 Restrictive Clothing • Do not insert the Sensor in any region that will sit beneath restrictive or very tight clothing as this may alter interstitial tissue perfusion • Altered tissue perfusion may inhibit “wetting” of the Sensor which can lead to longer initialization times, lost sensor alarms and data gaps

4. 3 Sensor Backing • Remove the transparent Sensor tape AFTER the Sensor has been placed in the SenSerter and BEFORE the Sensor is inserted • This will eliminate the need to remove the tape after Sensor insertion, and thus minimize pulling or dislodgement of the inserted Sensor

5. 4 Taut Skin • Hold the skin taut at the Sensor site. Do not pinch the skinas doing so may prevent optimal Sensor penetration 5 Needle Removal • Hold the base of the Sensor firmly. Pull the needle out smoothly in one motion and at the SAME ANGLE as inserted • Do not ROCK the Sensor when pulling out the needle, as this may jeopardize Sensor penetration and may damage the Sensor electrodes 6 Bleeding • If bleeding occurs after Sensor insertion, apply gentle pressure for 3 minutes

6. 7 Taping • After the MiniLink or iPro is connected to the Sensor, application of IV 3000 tape is highly recommended to: • Ensure the Sensor remains fully inserted underneath the skin • Maintain a tight Sensor to MiniLink or Sensor to iPro connection Reference electrode should sit beneath the skin inthe Subcutaneous Tissue Epidermis Dermis Subcutaneous Tissue Muscle

7. 8 One Minute Rule • WAIT 1 MINUTE after disconnecting the MiniLink or iPro from a Charger, Sensor or Tester and before connecting the MiniLink or iPro to a Sensor or Tester • The MiniLink or iPro may be connected to a Charger at any time • Once the MiniLink or iPro is connected to a Charger, the MiniLink or iPro must remain in the Charger for a MINIMUM OF 1 MINUTE

8. 9 MiniLink or iPro Flash • The MiniLink or iPro should flash green within 20 seconds AFTER it is connected to the Sensor • The flashing green light signals: • The Sensor is wet • There is enough power to last for a 3-day Sensor use Instruct patients to diligently check for the flashing green light

9. 10 Tester Procedure STEP1 Confirm the Sensor isfullyinserted for at least 5 minutes to ensure adequate “wetting” of the Sensor Make sure the MiniLink or iPro has a tight connection to the Sensor.Disconnect and reconnect the Sensor from the MiniLink if needed(utilizing the One Minute Rule). STEP2 Make sure the MiniLink or iPro is charged: Disconnect the MiniLink or iPro from the Sensor. Connect the MiniLink or iPro to the Charger. Allow to fully charge. Disconnect the MiniLink iPro from the Charger. Wait 1 minute. Reconnect the MiniLink or iPro to the Sensor. If the MiniLink flashes, continue with Sensor set-up. If the MiniLink does not flash go to Step 4. STEP3 Tester Procedure: Will Differentiate between a Sensor or a MiniLink / iPro Issue Disconnect the MiniLink or iPro from the Sensor. Wait 1 minute. Connect the MiniLink or iPro to the Tester. The Tester replicates a functioning Sensor with ISIG signals. Go to MENU > Sensor Status Screen. If the ISIG is between 24 and 29 nA, the MiniLink is functioning properly, thus the Sensor needs to be replaced. If the ISIG is < 24 or > 29 nA, call the 24-Hour Help Line, as the MiniLink or iPro may need to be replaced. STEP4 If the MiniLink or iPro does NOT flash when connected to the Sensor: