1 / 13

1 mV

1 mV. familial startle syndrome. Barbiturates Benzodiazepines Alcohol General Anesthetics. Chem. driving force. Elec. driving force. Rasmussen’s Encephalatis. Kainate Receptor. AMPA Receptor. Vc. +. Presynaptic glutamatergic Neuron. Postsynaptic Neuron. Vm = -35 mV.

rudolf
Download Presentation

1 mV

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. 1 mV

  2. familial startle syndrome Barbiturates Benzodiazepines Alcohol General Anesthetics

  3. Chem. driving force Elec. driving force

  4. Rasmussen’s Encephalatis Kainate Receptor AMPA Receptor

  5. Vc + Presynaptic glutamatergic Neuron Postsynaptic Neuron Vm = -35 mV NMDAR EPSC AMPAR EPSC Vm = -70 mV NMDAR EPSC AMPAR EPSC Glutamate receptor excitatory postsynaptic currents (EPSCs)

  6. Hippocampal long-term potentiation

  7. ionotropic receptors metabotropic receptors Effector

  8. Ionotropic receptor synaptic actions Metabotropic receptor synaptic actions Indirect Direct slower (0.1-100 s) fast (ms) open or close channels open synaptic channels resting channels, voltage-gated channels, fast synaptic channels channels only at synapse modulate excitability excite or inhibit AP

  9. ACh closure PIP2 PLC Gq DAG IP3 Ca release Protein kinase C

  10. 1.5 2. Decrease in slow delayed rectifier K current nA 1. Decrease in resting outward K current 0 1. Slow EPSP

More Related