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The Biology of Atherosclerosis, Heart Attacks and Strokes PowerPoint PPT Presentation


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The Biology of Atherosclerosis, Heart Attacks and Strokes. Bryan Holden. First Things First…. What is Atherosclerosis? - It is the progressive depositing of lipids and cells in the inner layer of an artery -It is the most common cause of heart attacks and strokes

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The Biology of Atherosclerosis, Heart Attacks and Strokes

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The Biology of Atherosclerosis, Heart Attacks and Strokes

Bryan Holden


First Things First…

What is Atherosclerosis?

-It is the progressive depositing of lipids and cells in the inner layer of an artery

-It is the most common cause of heart attacks and strokes

-Accounts for 75% of all cardiovascular disease deaths


Low Density Lipoprotein


The Mechanism of a Heart Attack

  • WBC’s adhere to luminal surface of the artery wall.

  • WBC’s differentiate into macrophages to fight an infection

  • Macrophages can readily endocytose LDL cholesterol into artery

  • Cholesterol is converted to an ester and is passed into the macrophage forming a foam cell


Accumulation of cholesterol forms a fatty streak


Smooth muscle cells secrete more cholesterol. A plaque is formed along with a fibrous cap


Plaque ruptures and forms a blood clot instantly


Blood clot results in…

Heart attack

Stroke

Death


Treatments

Balloon stretching

Removal of plaques

Stents

Bypass surgery


Prevention of Atherosclerosis

  • Exercise: 30 minutes most of the days of the week

  • Eat a diet low in saturated fats

  • Don’t smoke


Hazzah 4 Spring


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