1 / 82

Local and General Anesthetics

Local and General Anesthetics. By Sarah E. This is all questions!. This covers the bulk of the stuff we have to know about anesthetics, but not everything. Try to answer the questions before you click forward. They are designed to have short answers. First thing’s first. Local anesthetics.

rowena
Download Presentation

Local and General Anesthetics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Local and General Anesthetics By Sarah E.

  2. This is all questions! • This covers the bulk of the stuff we have to know about anesthetics, but not everything. • Try to answer the questions before you click forward. They are designed to have short answers.

  3. First thing’s first. Local anesthetics

  4. Local Anesthetics • List the amides (5) in order of fastest to slowest metabolism • Prilocaine (fastest) • Lidocaine • Mepivacaine • Ropivacaine • Bupivacaine (slowest)

  5. Local Anesthetics • Which form of the sodium channel do local anesthetics bind to? (resting, active, or inactive?) • Active or inactive (not resting) • Which form of the anesthetic binds to the sodium channel? (charged or uncharged?) • Charged • What side of the channel does the anesthetic bind to? (cytoplasmic or extracellular?) • cytoplasmic

  6. Local Anesthetics • What determines the potency of a local anesthetic? • Lipid solubility (more lipid soluble=more potent) • What determines the speed of onset of a local anesthetic? • pKa (lower usually means faster) • What can be administered to enhance uptake and prolong absorption of a local anesthetic? • epinephrine

  7. Local Anesthetics • What determines the duration of action of an LA? • Protein binding! And rate of degradation! (Esters are degraded faster. Amides have to get to the liver first) • What do opioids and/or clonidine do in conjuction with a LA? • Intensify the analgesia • How does acidosis (eg. from an abscess) affect a LA? • Decreases diffusion of the LA across the membrane, and also causes tachyphylaxis

  8. Local Anesthetics • Are local anesthetics weak acids or bases? • Weak bases • Which part of a sodium channel is closed during the resting stage? (h or m?) • m (it’s closer to the outside) • During the inactive stage? • h (it’s closer to the inside) • How many nodes of Ranvier have to be blocked by LA to block conduction? • 3

  9. Local Anesthetics Which are more sensitive: • Larger or smaller fibers? • Smaller • Myelinated or unmyelinated? • Unmyelinated • Central or peripheral fibers in a bundle? • Peripheral • A fibers or C fibers? • C (B fibers are between A and C)

  10. Local Anesthetics List the types of fibers in order from most to least sensitive: (6) • Pain • Autonomic • Temperature • Touch • Deep pressure • Motor

  11. Local Anesthetics List the esters in order of duration of action from shortest to longest (4). • Procaine • Chloroprocaine • Cocaine • Tetracaine

  12. Local Anesthetics Name 2 anesthetics that would be used for epidurals. • Bupivacaine and ropivacaine Why? • Because they both bind proteins and therefore do not cross the placenta easily Which one is better? • Ropivacaine Why? • Because it is less cardiotoxic. (Note: bupivacaine has its cardiotoxic effects BEFORE the CNS effects!)

  13. Local Anesthetics Name 2 drugs that are contraindicated for epidurals in pregnant women and why. • Mupivacainebecause it crosses the placenta and is toxic • Tetracaine because it causes motor paralysis (ok for spinal injections during C-section though).

  14. Local Anesthetics What would you give to a pregnant woman during emergency delivery? • Chloroprocaine Why are pregnant patients more susceptible to toxic effects of epidurals? • Increased blood flow to the epidural region

  15. Local Anesthetics Name all the local anesthetics we have to know that are hydrolyzed by cytochrome P450. • Prilocaine • Mupivacaine • Lidocaine • Ropivacaine • Bupivacaine

  16. Local Anesthetics Which drugs can lead to the formation of o-toluidine? • Prilocaine(and benzocaine)-forms methemoglobin How do you treat that? • Give methylene blue Which drugs can lead to the formation of PABA? • The esters Why does PABA matter? • Allergies!!! (The preservatives in the anesthetic injection can also cause allergies, and are suspected when someone has a reaction to an amide, since true amide allergies are rare.)

  17. Local Anesthetics What does giving sodium bicarbonate with a LA do? • Raises the local pH Who cares? • LAs are weak bases, so at higher pH, more are in the uncharged form and can cross membranes, increasing speed of action.

  18. Local Anesthetics What is usually the first sign of LA toxicity? • Circumoral numbness What are the steps in between that and death? • Tingling, tinnitus, nystagmus, anxiety, agitation, seizures • Cardiovascular toxicity occurs late-ish (except with bupivacaine) What are the cardiovascular effects? • Autonomic blockade! (so…hypotension, bradycardia, myocardial depression, arrhythmia)

  19. Local Anesthetics When is it ok to use cocaine? • In front of the police, you say? • No. You will go to jail. • TOPICALLY ONLY (opthalmic analgesia) • It has inherent vasoconstrictive properties! • Do NOT give as an epidural. What else can be used topically (and not necessarily for eyes)? • Tetracaine, but it’s less fun than telling your patients that you’re putting crack in their eyes.

  20. Moving on. Inhaled anesthetics

  21. Inhaled Anesthetics Name all seven inhaled anesthetics that we have to know (They are listed below in order of their MAC value). • Methoxyflurane (0.16) • Halothane (0.75) • Isoflurane (1.4) • Enflurane (1.68) • Sevoflurane (2.0) • Desflurane (6-7) • Nitrous oxide (105) I DOUBT you will have to know the numbers or the order EXCEPT for nitrous oxide

  22. Inhaled Anesthetics Are drugs with higher MAC values more potent or less potent? • Less potent—it takes more drug to get the same effect Do drugs with a higher lipid solubility have a higher MAC or a lower MAC? • Lower MAC (typically). More lipid solubility means more potency, typically.

  23. Inhaled Anesthetics Do drugs with a higher Blood:Gas partition coefficient equilibrate more quickly or more slowly) • More slowly—it takes a long time to saturate the blood since the blood can hold so much drug Does this matter? • It could lengthen induction time, but not necessarily. Some drugs have effects before they reach equilibrium (ie. the blood doesn’t have to be saturated)

  24. Inhaled Anesthetics Why can’t you use nitrous oxide alone? • It sucks. • Actually it doesn’t. It just has a MAC value of over 100%. So why do we use it at all? • It has very few side effects, so use in combo with lower doses of stronger (more toxic) anesthetics to decrease the likelihood of adverse effects. So what ARE the side effects of nitrous oxide? • Megaloblastic anemia due to effects on methionine synthase (ABUSERS ONLY) • accumulation in air spaces (blocked up middle ears, etc…)

  25. Inhaled Anesthetics Does nitrous oxide enhance other inhaled anesthetics? How or how not? • Yes. It absorbs into the blood quickly early on, increasing the relative concentration of the other anesthetics in the inhaled air. (second gas effect, minor clinically) What is diffusion hypoxia? • The reverse of the second gas effect. Nitrous oxide can come out of the blood and into the alveolus and decrease the relative concentration of oxygen. (minor, clinically)

  26. Inhaled Anesthetics Should you give loading doses of inhaled anesthetics? • No. Your patient will die (probably). The therapeutic indices for these drugs are low. What should you do? • Give IV anesthetics for rapid induction, if so desired.

  27. Inhaled Anesthetics Which gases can you induce with? (3.5) • Nitrous oxide • Halothane • Sevoflurane • Isoflurane sometimes for adults, but pretty pungent. Kids really don’t like it.

  28. Inhaled Anesthetics Name the 3 most popular inhaled anesthetics, currently. • Nitrous oxide • Desflurane • Sevoflurane What are the two historically important inhaled anesthetics on the list? • Nitrous oxide • Halothane

  29. Inhaled Anesthetics List the 5 components of general anesthesia. • Unconsciousness • Analgesia • Amnesia • Muscle relaxation • Progressive loss of reflexes Name a drug on the list that does all of these really well. • NONE.

  30. Inhaled Anesthetics List the 4 stages of general anesthesia. • Analgesia (block substantiagelatinosa) • Excitation (block inhibitory neurons) • Surgical anesthesia (depression of the RAS) • Apnea/death (depression of medulla) Where do all these effects happen, generally? • The CNS!!

  31. Inhaled Anesthetics Name 4 ways to measure consciousness • Respiration, reflexes, muscle tone, response to incision Are EEGs useful? • If there is just one anesthetic. Otherwise not really.

  32. Inhaled Anesthetics What determines which tissues get saturated first when giving inhaled anesthetics? • Blood flow! Which tissues have high flow? (4) • Brain, heart, liver, kidney Intermediate? (2) • Skin and muscle Low? (4) • Fat, bone, tendon, connective tissue

  33. Inhaled Anesthetics What does the term “Fa/Fi” stand for? • Fa= the gas concentration of a drug in the alveolus AFTER gas exchange has occurred. • Fi= gas concentration of a drug in the alveolus INITIALLY (before absorption happens) What does it mean when this term is 100%? • The drug is at equilibrium. Nothing more can be absorbed into the blood because it is saturated.

  34. Inhaled Anesthetics Does a more soluble drug reach equilibrium more quickly? • No. It takes longer to “fill up” the blood. What value is inversely proportional to solubility? • MAC value! (as solubility increases, the effective inhaled concentration decreases (it gets into the blood more quickly, even if it takes longer to saturate Are more soluble drugs more or less potent? • More potent! (One exception on next slide)

  35. Inhaled Anesthetics What are the 2 most insoluble agents on our list? • Nitrous oxide and desflurane Of those two, which is more POTENT? • Desflurane (even though it is less soluble than nitrous oxide)

  36. Inhaled Anesthetics Is induction faster with more soluble or more insoluble agents? • Tricky question. More soluble drugs tend to be more potent, though it takes a long time to saturate the blood. Remember that you don’t need to saturate the blood to get the effects. Seems that most of the time, insoluble agents act faster. Is emergence from anesthesia faster with more soluble or more insoluble agents? • More INSOLUBLE because they don’t like being in the blood. The patient breathes them out faster

  37. Inhaled Anesthetics Is induction faster in a patient with a higher cardiac output? • No. It takes longer to saturate the blood. How do halogenated anesthetics affect respiration? • Decrease volume, increase rate • All are bronchodilatory except Desflurane How do halogenated anesthetics affect blood pressure? • Decrease BP ICP? • increased

  38. Inhaled Anesthetics Name 4 components of balanced anesthesia. • pre-anesthetic • induction anesthetic • maintenance anesthetic • neuromuscular blocking agent

  39. Woot. Specific Inhaled Anesthetics

  40. Nitrous Oxide Can it be used for induction? • Yes, but not alone. Are induction and recovery fast or slow? • Fast (because it’s pretty insoluble in the blood) Analgesia? • Yes! It’s very good.

  41. Nitrous Oxide Metabolism? • Breath it back out. No significant metabolism. When should you NOT use this drug? • When patients have pockets of trapped gas(eg. Middle ear occlusion, pneumothorax, intestinal loop, etc…) Mechanism of action? (yes, this one is known) • Blocks NMDA receptors Any side effects? • Megaloblastic anemia due to effects on methionine synthase IN ABUSERS

  42. Halothane Can it be used for induction? • Yes. Not pungent! Are induction and recovery fast or slow? • Fairly fast Cardiac effects? • Decreases cardiac output and blood pressure, SENSITIZES TO CATECHOLAMINES, which means ARRHTYMIAS Muscle effects? • Only slight relaxation of skeletal. Relaxes smooth muscle, increasing ICP (and decreasing BP)

  43. Halothane Analgesia? • Only slight analgesia Metabolism? • ~20%. The rest is breathed out. Any side effects? • Toxic metabolite: Fluoride ion, decreases renal function! • Halothane hepatitis! -1/35000 cases, 2-5 days post-op When should you NOT use this drug? • (On days that end in “y”?) Pretty much nobody uses this drug anymore because there are much better options

  44. Isoflurane Can it be used for induction? • Yeah, but not for pediatric patients. How does its potency and solubility compare to halothane? • Less potent, less soluble. How does speed of induction and emergence compare to halothane? • Faster!

  45. Isoflurane Cardiac effects? • Decreases BP, Increases HR, same CO Arrhythmias? • No. Muscle effects? • Potentiates non-depolarizing blockade Metabolism? • Much less than halothane. Cost as compared to halothane? • More expensive

  46. Enflurane Can it be used for induction? • No. Too pungent. Speed of induction and emergence? • So-so. There’s better, less soluble stuff. Cardiac effects as compared to halothane? • All are less bad, even ICP (but still there) Muscle effects as compared to halothane? • More skeletal muscle relaxation When should you not use this drug? • In kids and people with abnormal EEG because it can induce seizures in sensitive patients.

  47. Methoxyflurane More or less soluble than halothane? • WAY more soluble, more potent Speed of induction and emergence? • VERY SLOW (because it’s so soluble) When should you not use this drug? • (When the next best option is to just get your patient really really drunk?) This drug is no longer in clinical use because of it’s slow speed and high toxicity

  48. Sevoflurane More or less soluble than halothane? • Less soluble, more potent Mask induction? • Yep! Speed of induction and emergence? • Fast, and offers excellent control Respiratory? • Bronchodilation Metabolism? • 3% More or less toxic than isoflurane? • More toxic

  49. Desflurane Mask induction? • Absolutely not. Causes laryngospasm and irritation. Faster or slower induction than sevoflurane? • Faster. (5-10 min. recovery! Ambulatory surgery) Respiratory? • Bronchoconstriction (from all that irritation!) Cardiac? • Increases heart rate and CO! (because increased catecholamine release) Metabolism? • Very little Suitable for pediatric patients? • No.

  50. More Inhaled Anesthetic Questions Hang in there!

More Related