Cerebral Malaria. severe complication of falciparum malaria mortality of 30-50% associated with sequestration in micro-vasculature of brain a diffuse encephalopathy with loss of consciousness consciousness ranges from stupor to coma unresponsive to pain, visual, and verbal stimuli
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Complications Associated with Falciparum Malaria
Features Indicating Poor Prognosis in Severe Malaria
Higher Parasitemias in Falciparum Malaria
P. falciparum expresses ‘knobs’ on the surface of infected erythrocytes. Knobs mediate cytoadherence to endothelial cells.
Several Parasite Proteins Are Associated with Knobs
Possible Host Receptors
hypoxia, metabolic effects
Problems with Sequestration Hypothesis