1 / 7

Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial

Phase 3. HIV Coinfection. Treatment Naïve and Treatment Experienced. Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial. Molina JM, et al. IAC. 2014; Abstract MOAB0105LB. Sofosbuvir plus Ribavirin for HCV-HIV Coinfection PHOTON-2 Trial: Study Features.

ronat
Download Presentation

Sofosbuvir + Ribavirin in HCV- HIV Coinfection: HCV GT 1,2,3,4 PHOTON-2 Trial

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Phase 3 HIV Coinfection Treatment Naïve and Treatment Experienced Sofosbuvir + Ribavirin in HCV-HIV Coinfection: HCV GT 1,2,3,4PHOTON-2 Trial Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  2. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Study Features Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  3. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Overall Demographics Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  4. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Treatment Arms Week 0 12 24 36 GT 1,3,4 Naïve Sofosbuvir +RBV(n = 200) SVR12 GT 2 Naïve Sofosbuvir +RBV(n = 19) SVR12 GT 2,3 Experienced Sofosbuvir +RBV(n = 55) SVR12 Drug DosingSofosbuvir: 400 mg once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  5. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV x 12-24 weeks 95/112 17/19 52/57 26/31 5/6 42/49 Treatment Naive Treatment Experienced All received 24-week Rx except 12 week Rx with GT-2 Treatment Naive Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  6. Sofosbuvir plus Ribavirin for HCV-HIV CoinfectionPHOTON-2 Trial: Results PHOTON-2: SVR 12 with Sofosbuvir + RBV, by Genotype 95/112 22/25 94/106 26/31 Source: Molina JM, et al. IAC. 2014; Abstract MOAB0105LB.

  7. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

More Related