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Microprosthetic Implant for the Treatment of Erectile Dysfunction

Microprosthetic Implant for the Treatment of Erectile Dysfunction. Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher. Thesis. A microprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. Minimally invasive

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Microprosthetic Implant for the Treatment of Erectile Dysfunction

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  1. Microprosthetic Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher

  2. Thesis • A microprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. • Minimally invasive • Patient compliance • Targeted drug release and control

  3. Erectile Dysfunction Background • Erectile Dysfunction (ED) • Prevalence in men 40-70 = 52%1 • Current treatment options • Prescription oral pills • Injection therapy • Penile prosthetics • Drug therapy market size • $3.1 billion in 2005 • Estimated growth of 6.5% annually through 20102

  4. Codman 3000 and IsoMed Pumps • Refillable drug delivery • No power supply • Pain management and chemotherapy • Constant flow, different models • Modify with trigger mechanism, one way valve, and power supply • 510k approval

  5. Drug Selection and Flow • Papaverine hydrochloride plus phentolamine • Concentration of 50 mg/mL • Expected dosage of 10 mg = .2 mL • Less than with injection • 10mg*(1mL/50mg) = .2 mL • 50 mL reservoir • 250 doses per refill • 50 mL * (1 dose/.2 mL) = 250 doses

  6. Prototype Fabrication Materials

  7. Prototype Fabrication

  8. Prototype Valve Fabrication

  9. References • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Urology 1994; 151: 54-61. • Elder, Melissa. Men’s Health: The Worldwide Market for Current and Emerging Drug Therapies, 2nd ed. Kalorma Information. May 2006. • Robert C. Dean, MD and Tom F. Lue, MD. Physiology of penile erection and pathophysiology of erectile dysfunction. UrolClin North Am. 2005 November; 32(4): 379-v. • “Codman 3000.” Codman Pumps. 15 Oct. 2009. Web. <http://www.codman.com/DePuy/products/Products/neuromodulation/pump/index.html>. • Sacral Plexus of the Right Side. Gray’s Anatomy.

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