1 / 31

West Pharmaceutical Services Reusable Injectable Drug Delivery

West Pharmaceutical Services Reusable Injectable Drug Delivery. Team West Pharmaceutical Services Sponsors: Reginald Motley and Chris Evans Advisor: Dr. Singh BMEG: Ryan O ’ Boyle, Madison DeFrank , and Derek Hunter MEEG: Hayley Shaw and Kailey Nelson. BMEG450/MEEG401. 12/11/13.

roman
Download Presentation

West Pharmaceutical Services Reusable Injectable Drug Delivery

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. West Pharmaceutical Services ReusableInjectable Drug Delivery Team West Pharmaceutical Services Sponsors: Reginald Motley and Chris Evans Advisor: Dr. Singh BMEG: Ryan O’Boyle, Madison DeFrank, and Derek Hunter MEEG: Hayley Shaw and Kailey Nelson BMEG450/MEEG401 12/11/13

  2. Background Pharmaceutical Packaging Systems Pharmaceutical Delivery Systems • 2012 Revenue: $915million • Market Leader • Global Manufacturing • Innovative and Proven Product Portfolio • 2012 Revenue: $352 million • Proprietary Devices/Delivery System Technologies • Collaborative Development • Contract Manufacturing Development Primary Package Administration Patient 12/11/13

  3. Motivation West hopes to expand their product line to include a range of products that are reusable. This would reduce wastes and overall costs Scope To research and develop a novel drive mechanism that can be reset and move a piston in a 1 mL syringe for dispensing of liquid 12/11/13

  4. Product Line SelfDose Confidose SmartDose • Disposable • Spring, motor, manually driven • Easy to use • At home use • Not on market yet 12/11/13

  5. Benchmarking Competing Products • Unilife LISA Auto-injector System • BD Pen II Reusable Pen • Cambridge Consultants Flexi-Ject Auto-injector 12/11/13

  6. Design Requirements 12/11/13

  7. Concept Generation • Round 1 • Shape Memory Alloy • Soft Metal Alloy • Flat Coil Spring • Motor Driven • Hydraulic Component • Round 2 • Neodymium Magnets • Chemical Reaction • Coil Wire/ Electromagnetic Force FINAL CONCEPT: Shape Memory Alloy • Top 2 Concepts • Shape Memory Alloy • Neodymium Magnets 12/11/13

  8. ShapeMemoryAlloy • Deformable alloy material • Returns to original shape when heated • Nitinol = nickel + titanium • Transition temperature is 70-80oC • Nitinol springs used as driving force 12/11/13

  9. Nitinol Spring Video 12/11/13

  10. Preliminary Testing • 1 Spring tested • Two different vendors • Spring displacement held constant Spring 1: Spring 2: Conclusion: Spring 2 provides a more cost effective solution. 12/11/13

  11. Final Prototype Drive Mechanism Battery Pack Syringe Toggle Switch 12/11/13

  12. Design Overview Inner Assembly Top Platform • Lined with heat shielding tape • Fiberglass tape shields 260oC • Foil tape reflects 815oC • 8 stretchable Nitinol springs • 11.1 V battery pack • 3.5 A through each spring • High-amp toggle switch Plunger Rod Nitinol Springs Bottom Platform Syringe 12/11/13

  13. Design Overview Outer Assembly Top Casing • Prefilled syringe inserted through bottom platform • Locking platform secures syringe • Springs supply up to 16.9 lb force • Can be reset to prepare for new injection • New syringe inserted after injection Inner Assembly External Casing Syringe Locking Platform 12/11/13

  14. Validation Testing Observational Testing 12/11/13

  15. Validation Testing Experimental Testing 12/11/13

  16. Cost Analysis Purchased Parts Prototype Cost (per unit) 46.6% of Budget Spent 12/11/13

  17. Path Forward • Optimize force generated: use Nitinol springs of different composition • Use ultra-capacitors in order to eliminate the need for a large battery • Coating in heat shielding material during manufacturing stages • Downsizing the system to maximize compactness • Incorporate automatic shut off system • Increase safety • Decrease spring fatigue. 12/11/13

  18. Thank you! Questions? 12/11/13

  19. Delrin • Polyoxymethylene (Acetel) Resin • Melting point = 175oC • Can be injection molded Manufacturing CostPer Unit (1000 units made) 56.1% Decrease! 12/11/13

  20. Stress Analysis Applied Force: 10 lbs Applied Force: 18 lbs

  21. Viscosity Testing

  22. Failure Testing A trial was deemed a failure if a full dose of liquid was not dispensed or heat of the springs produced visible smoke.

  23. Magnet Concept • Magnets were very difficult to work with • Preliminary testing showed that concept was unable to displace plunger of an empty syringe

  24. Magnet Testing 1

  25. Magnet Testing 2

  26. Concept Generation Round 1 • Shape Memory Alloy • Soft Metal Alloy • Motor Driven • Flat Coil Spring • Hydraulic Component

  27. Concept Selection Round 1 Winning Concept = Shape Memory Alloy!

  28. Concept Generation Round 2 • Chemical Reactions • Potassium Chlorate + Sugar • Magnet Gun • Solenoid Coil Gun

  29. Concept Selection Round 2 Winning Concept = Magnet Concept!

  30. Current Optimization

  31. Working Prototype

More Related