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National Specialist Dermatopathology EQA Scheme. Circulation L. Case number: 185 Clinical: Male aged 70 years. ?BCC Immuno: Pancytokeratin shows strong positivity in centre of lymphoid islands. EBV negative. Most popular diagnosis Lymphoepithelioma-like carcinoma .

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slide2

Case number: 185

  • Clinical: Male aged 70 years. ?BCC
  • Immuno: Pancytokeratin shows strong positivity in centre of lymphoid islands. EBV negative.
slide10

Most popular diagnosis

  • Lymphoepithelioma-like carcinoma
slide11

Case number: 186

  • Clinical: Male 44. Excision of irritated skin lesion behind right ear.
  • Specimen: Skin tag.
  • Macro: A grey polypoid fragment of skin 9x5x5mm.
slide18

Most popular diagnosis

  • Epithelioid haemangioma
slide19

Case number: 187

  • Female 65 yrs.
  • Extending atrophic white plaque left anterior iliac region.
  • Macro: Elliptical piece of skin 20x6x6mm.
slide27

Case number: 188

  • Female aged 62.
  • ?Multiple cysts posterior neck.
  • Specimen: Punch biopsy
  • Macro: 3x3x4mm punch biopsy.
slide32

Most popular diagnosis

Malignant, probably metastatic lobular breast 9.70

slide33

Case number: 189

  • Female aged 48 years.
  • A.L.L. Had bone marrow transplant .
  • Had susequentGvHD.
  • Now thickened red, swollen skin
  • ?Leukaemic infiltrate.
  • Positive for CD79a, CD20, CD10, CD34, TdT.
  • Negative for CD2, CD3 and CD117.
slide38

Most popular diagnosis

  • B lymphoblastic lymphoma
slide39

Case number: 190

  • Male aged 21 years.
  • Skin lesions from back ??melanoma .
  • Macro: A large ellipse of skin 75x33x25mm with a central area of depigmentation 37x25mm surrounded by slightly reddish periphery.
slide45

Case number: 191

  • Male aged 60 years.
  • Skin left poplitealfossa excision. Five week history of nodule on skin. No pus. Has some insect bites. ?insect bite reaction, ?keratoacanthoma versus SCC.
  • Macro: Skin biopsy 18x13x2mm in depth with a centrally raised slightly keatotic lesion 5mm in diameter.
slide55

Case number: 192

  • Female aged 64 years.
  • Ultra sound \'vascular lump\'.
  • Specimen: Lesion right neck. Excision
  • Macro: Skin ellipse 35x26mm with raised smooth lesion 25x18x10mm.
slide59

Most popular diagnosis

  • Granular cell tumour
slide60

Case number: 193

  • Female aged 22 years.
  • Pruritic papules and vesicles.
  • IMF shows granular IgA in the dermal papillae.
  • Macro: Punch biopsy 4x4mm deep.
slide63

Most popular diagnosis

  • Dermatitis herpetiformis
slide64

Case number: 194

  • Male aged 88 years.
  • 2-3 month history of mass on left thigh.
  • TTF-1 negative, CK7 negative, S100 negative.
  • CK20 positive, Chromogranin positive, CD56 positive, Synaptophysin positive.
  • Ellipse of skin 80x10mm with 20mm depth bearing a pink nodule15mm dimension.
slide67

Most popular diagnosis

  • Merkel cell carcinoma
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