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Aim Investigate circulatory levels of biomarkers for muscle damage.

Plasma variation of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. Sandra Loerakker, MSc; Elise S. Huisman, MSc; Henk A. M. Seelen, PhD; Jan F. C. Glatz, PhD; Frank P. T. Baaijens, PhD; Cees W. J. Oomens, PhD; Dan L. Bader, PhD. Aim

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Aim Investigate circulatory levels of biomarkers for muscle damage.

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  1. Plasma variation of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects Sandra Loerakker, MSc; Elise S. Huisman, MSc; Henk A. M. Seelen, PhD; Jan F. C. Glatz, PhD; Frank P. T. Baaijens, PhD; Cees W. J. Oomens, PhD; Dan L. Bader, PhD

  2. Aim • Investigate circulatory levels of biomarkers for muscle damage. • Explore possibility of using them to detect deep pressure ulcers. • Relevance • Deep pressure ulcers are major problem for people with spinal cord injury (SCI) • Initial damage often hidden underneath intact skin. • Early detection is difficult and treatment is problematic.

  3. Methods • In small groups of nondisabled subjects and subjects with SCI, we measured 5-day baseline concentrations of: • Creatine kinase. • Myoglobin (Mb). • Heart-type fatty acid binding protein (H-FABP). • C-reactive protein (CRP).

  4. Results • Each subject had unique marker concentration profile. • Mb and H-FABP were correlated for both subject groups. • No significant differences in marker concentrations between groups, although trend toward higher CRP was observed in SCI subjects. • One SCI subject with category II pressure ulcer had higher H-FABP and CRP concentrations than all other subjects.

  5. Conclusions • Variations in each marker concentration were smaller than predicted increases after pressure ulcers. • Therefore, this combination of plasma markers may prove appropriate for early detection of deep pressure ulcers.

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