Welcome to the molecular medicine course
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Welcome to the Molecular Medicine course!. Registration. General information Over-arching goals Roll call Course contents Information about KS library Coffee Course evaluation HT 2011 Study design - research application + presentations Seminar assignment Final examination

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Welcome to the Molecular Medicine course!

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Welcome to theMolecular Medicinecourse!


Registration

  • General information

  • Over-arching goals

  • Roll call

  • Course contents

  • Information about KS library

  • Coffee

  • Course evaluation HT 2011

  • Study design - research application + presentations

  • Seminar assignment

  • Final examination

  • Molecular Medicine - from bed to bench


Course leader: Rachel Fisher

08-517 732 45rachel.fisher@ki.se

Deputy course leader: Ewa Ehrenborg

08-517 761 91ewa.ehrenborg@ki.se

Teaching assistant: Louisa Cheung

08-517 732 21 louisa.cheung@ki.se

Department of Medicine, Center for Molecular Medicine,

Karolinska University Hospital, L8:02

Course administrator: Eva MacDonald

Department of Medicine, Unit for Internal Medicine,

Karolinska University Hospital, A3:02

08-517 716 33eva.macdonald@ki.se

Office hours daily 8.00am - 3.00pm


Over-arching goals

  • To integrate previously gained knowledge

  • To stimulate team work

  • To analyse, evaluate and interpret raw data

  • To design a study and write a research application

  • To provide “real life” experience


Roll call


Course set up

  • Lectures usually 9am – 3pm (check venue!)

  • Labs/demonstrations/seminars usually in groups

  • Time scheduled for group work

  • Seminar assignment

  • Presentation of group work (research application) at end of course

  • Revision time

  • Final written examination: 15th January


  • Course contents (15 hp/ECTS)

  • Specific areas

  • Circulation, ischemia, metabolic syndrome, diabetes

  • Respiration, asthma, allergy

  • Endocrinology

  • Gastroenterology

  • Pathology

  • Clinical immunology / Clinical chemistry

  • Assignments etc.

  • Molecular biology lab

  • Research application

  • Seminar assignment

  • Workshops

  • Revision


Course literature

  • Text books from previous courses:

    physiology, pharmacology, biochemistry,

    molecular genetics, immunology

  • Articles and links on the web page

  • Lecture summary points (from lecturers)


Information about KS libraryMarie Källberg


Seminar assignment

Lab “Methods in Molecular Biology”

Lectures, demos, labs, exam

Workshops

Research plan


  • Labs and Demonstrations

  • Lab: “Methods in Molecular Biology – Theory and Practice”

  • 12/11 (introduction)27-29/11, 4-6/12 (lab)12-14/12 (analysis + statistics)9/12 (discussion + review)

  • Angiography demonstration (14/11)

  • Blood grouping lab (15-16/11)

  • Lung/allergy demonstration (20/11)


  • Labs

  • You must bring your own lab coatCompulsory to have a lab coat to perform the labs

  • If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr):http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma)

  • Some labs and demonstrations will be performed in active research labs- show consideration for those who work there


  • Blood groupingThur 15/11,9–12

  • Methods Mol BiolTue 27/11

Groups

  • Blood groupingFri 16/11,9–12

  • Methods Mol BiolWed 28/11

  • Blood groupingThur 15/11,13–16

  • Methods Mol Biol

  • Tue 4/12

  • Blood groupingFri 16/11,13–16

  • Methods Mol Biol

  • Wed 5/12


Course evaluation HT 2011

Good

  • Research application

  • Lab “Methods in Molecular Biology”

  • Seminar assignment

  • Course leaders/administration

    Mixed

  • Clinical emphasis

  • Blood grouping lab

  • Lung/asthma/allergy demonstration

  • Lecturers

    Bad

  • Lack of a course text book

  • Some repetition within lectures

  • Too many lectures


New for HT 2012

  • Some lectures + pathology seminars removed

  • Workshops

  • Modified set up for Lab “Methods in Molecular Biology”

  • Place blood grouping lab in context

  • Modified lung/asthma/allergy demonstration

  • Final examination after Christmas

  • Presentation of research applications at end of course


  • Workshops

  • 3 workshops:Atherosclerosis(12/11)Endocrinology(21/11)Diabetes/Metabolism(11/12)

  • Questions/discussion topics handed out in connection with relevant lectures

  • Self-study/discussion + review with teacher

  • Preparation for the exam


Evaluation of the course

  • We rely on your feedback to improve the course

  • Please give constructive feedback

  • Evaluation forms (online)

  • Cinema ticket voucher if all evaluation forms completed + submitted!


Course councils

  • With class representativesWednesday 21st November, 12 noon

  • With whole classThursday 17th January, 3pm

  • Who are the class representatives?


Forms of feedback

reviewing progress with  students

Round-table feedback

Methods in mol biol

Research application

feedback on seminar assignment & exam

Peer-to-peer to edit and redraft

Methods in mol biol

Pre-submission guidance and feedback

Research application

Workshops

feedforward assignments

Research application

Informing about feedback

whole-class feedback

Workshops

Course councils and evaluations


Course language

  • All literature in English

  • Lectures in English

  • All assignments may be written in either English or Swedish


Research application

  • Group assignment

  • Choose a specific issue to focus on

  • Design a research project

  • Write a research application

  • Present the project orally

  • Answer questions

  • Team work

  • Realistic exercise


Research application:groups and topics

  • Groups 1-6 each split in 2

  • 12 ”subgroups” of 3-4 people

  • Each subgroup allocated a broad topic

  • Detailed project chosen by the subgroup

  • Discussions with and feed back from topic ”mentor”


MicroRNA and vascular disease

Aneurysm

Thyroid diseases

Thrombosis and haemostasis

Mesenchymal stem cells and bone formation

Cell death in metabolism

Metabolism and cardiovascular disease

Immunological aspects of gastric disease

Inflammation in cardiovascular disease

Allergy

Diabetes and co-morbidities

Vascular remodelling

Research application – broad topics

2 topics/group, 3-4 people/research application


Research applicationtopic lottery


Seminar assignment

  • Handed out at course start

  • Group work / individual assessment

  • Research based aspects, requires independent work

  • Obtain appropriate information- lectures, discussions, web, articles ..…

  • Time scheduled to prepare answer

  • Presentation of assignment in seminar format:Groups 4, 5 + 6Wednesday 28th NovemberGroups 1, 2 + 3Wednesday 5th December

  • Grading = pass / fail


Time in schedule for Groups 1, 2 + 3to work with seminar assignment


Time in schedule for Groups 4, 5 + 6to work with seminar assignment


Examination

  • Final examination: Tuesday 15th January Grades A-F

  • Questions testing knowledge + understanding


Grading of the examination

  • F, Fx, E, D, C, B, A

  • Goal-based assessment

  • Evaluating the level of knowledge obtained not the amount of knowledge

  • F, Fx = fail

  • E = basic pass: identify, describe, list

  • C, D = pass with merit: compare, explain connections, analyse, apply

  • B, A = pass with distinction: theorise, hypothesise, reflect


One relevant

aspect

Several relevant

independent aspects

Integrated into

a structure

Generalized to

new domain

Extended abstract

B, A

Relational

C, D

Prestructural

F

Multistructural

E

Unistructural

Fx


To pass the course …

  • The student must obtain a grade of at least E for the written examination (5 hp)

  • The student must also pass

    • the seminar assignment (3 hp)

    • the research application (3 hp)

    • all labs and demonstrations (4 hp)


Replacement assignments

  • When compulsory parts of the course are missed, there are replacement exercises

  • If written, these must be handed in by the last day of the course (18 January 2013)

  • Next opportunity for submission = next course (HT2013)


Information about Masters Programme

  • Wednesday 21st November, 1pmLars-Arne HaldosénLena Hansson


Molecular Medicine:from bed to bench

  • Important clinical contact

  • Translational research

  • Cross-disciplinary

  • “From bench to bed and back again”


Please use the web page!


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