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Nens220, Lecture IX Oscillations, resonance, synchrony, biophysically-based neuronal networks

Nens220, Lecture IX Oscillations, resonance, synchrony, biophysically-based neuronal networks. John Huguenard. Neuronal oscillations: functions. Sleep Generate activity that is independent of sensory input May play roles in memory consolidation or reprioritization.

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Nens220, Lecture IX Oscillations, resonance, synchrony, biophysically-based neuronal networks

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  1. Nens220, Lecture IX Oscillations, resonance, synchrony, biophysically-based neuronal networks John Huguenard

  2. Neuronal oscillations: functions • Sleep • Generate activity that is independent of sensory input • May play roles in memory consolidation or reprioritization. • Spindles, delta, sharp-wave ripple complexes • Awake behavior • Exploration – theta • Sensory binding & attention – gamma • Sensory discrimination – olfaction in insects • Pathology • Epilepsy • Parkinson’s disease

  3. Neuronal oscillations: mechanisms • Intrinsic neuronal properties • Resonance • Network feedback • Can interact with neuronal properties to reinforce or cancel network responses • Dynamics • Initiation • Propagation • Termination

  4. Determining neuronal resonance Gutfreund et al, J Physiol. 483:621, 1995

  5. Resonance and coding space • “Grid” cells in in entorhinal cortex part of space encoding network. Hafting .. Moser Nature 436:801, 2005

  6. Resonance and coding space • “Grid” cells in in entorhinal cortex part of space encoding network. Alonso & Llinas Nature 342:172, 1989 Giocomo et al Science, 315:1719, 2007

  7. Resonance and coding space • “Grid” cells in in entorhinal cortex part of space encoding network. Giocomo et al Science, 315:1719, 2007

  8. Resonance in thalamic relay neurons

  9. Thalamic reticular cells:Intrinsic oscillators Avanzini et al J Physiol. 416:111, 1989

  10. Thalamic reticular cellsMechanisms of intrinsic oscillations Wallenstein, Biophys J 66:978, 1994

  11. K complex and spindles in early sleep Courtesy of K. Graber

  12. The thalamocorticalsystem Corpus striatum • Sensory relay • Sleep oscillations A VA RE VL M VP LP Pu LGN MGN Drawing from Dr. Wolfgang Klimesch

  13. Intracellular studies of spindles in vivo Modified from Steriade and Llinás. Physiol.Rev. 68:649-742, 1988.

  14. Cx + Thalamus: Inhibitory network oscillations

  15. Modeling a large scale thalamocortical network Destexhe (1998) J. Neurosci. 18, 9099-9111.

  16. Modeling a large scale thalamocortical network Destexhe (1998) J. Neurosci. 18, 9099-9111.

  17. Modeling a large scale thalamocortical network Destexhe (1998) J. Neurosci. 18, 9099-9111.

  18. 250 pA 2.5 ms 250 pA Fran Shen

  19. Dynamic-Clamp: Artificial Autaptic IPSCs Based on Fuhrmann, et al. J Neurophysiol 87: 140–148, 2002

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