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Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?. Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery University of Ilorin Teaching Hospital ,Ilorin. Introduction.

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Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?

AdemolaPopoola ,BUHARI TAJUDEEN ,FidelisUshie ,HamidOlanipekun.

Department of Surgery

University of Ilorin Teaching Hospital ,Ilorin.


Introduction
Introduction cancer and other primary tumors: any link or coincidences?

  • Prostate cancer is the most commonly diagnosed malignancy affecting men beyond middle age.

  • Is the most common non cutaneous malignancy in the Western world.

  • 2nd leading cause of cancer death in men.

  • It is a major public health burden in Sub Sahara Africa.

  • In practice, prostate cancer has been reported to occur simultaneously (synchronous) or successively (metachronous).


  • Some multiple cancer syndromes have been well defined. These include Von HippelLindau Syndrome (cerebellar & retinal heamangioma, renal, pancreatic and spinal meningeal tumors).


Aim cancer and other primary tumors: any link or coincidences?

  • To report Multiple Primary Cancers (MPC) involving Prostate cancer in our centre in the last two years.

  • To identify from the literature possible associations of simultaneously occurring cancers.


Methodology
Methodology cancer and other primary tumors: any link or coincidences?

  • Retrospective analyses from our database of patients with MPC involving prostate cancer in the last two years.

  • Review of existing literature for possible association.


Discussion
Discussion cancer and other primary tumors: any link or coincidences?


Discussion cont d
Discussion [Cont’d] cancer and other primary tumors: any link or coincidences?

  • Prostate cancer could occur with other primary tumours as synchronous or metachronous.

  • This has been adduced to increased life span and improved diagnostic tools.

  • There are existing literatures reporting prostate cancer occurring with all the other primary tumors in our series.

  • Lee et al; reported 4.03% finding of prostate cancer in radical cystoprostatectomy specimen (Asian J. Andrology, 2006).


Discussion cont d1
Discussion [Cont’d] cancer and other primary tumors: any link or coincidences?

  • The incidence of other primary tumours in the setting of primary liver cell carcinoma is relatively common with a strong clustering of genitourinary and gastro-intestinal malignancies.

  • Synchronous thyroid tumours have been reported following radiation for head and neck tumours. In our report, it was discovered after External beam radiation therapy to the pelvis.

  • Prostate cancer with Rectal cancer

    - Post Radiotherapy

    - Age


Discussion cont d2
Discussion [Cont’d] cancer and other primary tumors: any link or coincidences?

  • Prostate cancer with Colonic tumours

    - Genetics: (i) mutation of BRCA2 gene

    (ii) mutation of MMR gene (Lynch syndrome)


Challenges
Challenges cancer and other primary tumors: any link or coincidences?

  • To make Diagnosis.

  • Diagnostic tools are limited: availability and affordability.

  • Between oncologic cure and preservation of functional anatomy/quality of life.

  • No established guideline.

  • Poor cancer registry.

  • Low rate of postmortem and radical procedures.


Conclusion
Conclusion cancer and other primary tumors: any link or coincidences?

  • MPC occurrence are probably more than the documented cases.

  • Detailed clinical evaluation is key.

  • There is need for more multidisciplinary approach to care.

  • There is also need for genetics study.


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