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Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery

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Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery - PowerPoint PPT Presentation


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Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?. Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery University of Ilorin Teaching Hospital ,Ilorin. Introduction.

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Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?

AdemolaPopoola ,BUHARI TAJUDEEN ,FidelisUshie ,HamidOlanipekun.

Department of Surgery

University of Ilorin Teaching Hospital ,Ilorin.

introduction
Introduction
  • Prostate cancer is the most commonly diagnosed malignancy affecting men beyond middle age.
  • Is the most common non cutaneous malignancy in the Western world.
  • 2nd leading cause of cancer death in men.
  • It is a major public health burden in Sub Sahara Africa.
  • In practice, prostate cancer has been reported to occur simultaneously (synchronous) or successively (metachronous).
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Introduction [Cont’d]

  • Some multiple cancer syndromes have been well defined. These include Von HippelLindau Syndrome (cerebellar & retinal heamangioma, renal, pancreatic and spinal meningeal tumors).
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Aim
  • To report Multiple Primary Cancers (MPC) involving Prostate cancer in our centre in the last two years.
  • To identify from the literature possible associations of simultaneously occurring cancers.
methodology
Methodology
  • Retrospective analyses from our database of patients with MPC involving prostate cancer in the last two years.
  • Review of existing literature for possible association.
discussion cont d
Discussion [Cont’d]
  • Prostate cancer could occur with other primary tumours as synchronous or metachronous.
  • This has been adduced to increased life span and improved diagnostic tools.
  • There are existing literatures reporting prostate cancer occurring with all the other primary tumors in our series.
  • Lee et al; reported 4.03% finding of prostate cancer in radical cystoprostatectomy specimen (Asian J. Andrology, 2006).
discussion cont d1
Discussion [Cont’d]
  • The incidence of other primary tumours in the setting of primary liver cell carcinoma is relatively common with a strong clustering of genitourinary and gastro-intestinal malignancies.
  • Synchronous thyroid tumours have been reported following radiation for head and neck tumours. In our report, it was discovered after External beam radiation therapy to the pelvis.
  • Prostate cancer with Rectal cancer

- Post Radiotherapy

- Age

discussion cont d2
Discussion [Cont’d]
  • Prostate cancer with Colonic tumours

- Genetics: (i) mutation of BRCA2 gene

(ii) mutation of MMR gene (Lynch syndrome)

challenges
Challenges
  • To make Diagnosis.
  • Diagnostic tools are limited: availability and affordability.
  • Between oncologic cure and preservation of functional anatomy/quality of life.
  • No established guideline.
  • Poor cancer registry.
  • Low rate of postmortem and radical procedures.
conclusion
Conclusion
  • MPC occurrence are probably more than the documented cases.
  • Detailed clinical evaluation is key.
  • There is need for more multidisciplinary approach to care.
  • There is also need for genetics study.
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