1 / 11

Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery

Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences?. Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery University of Ilorin Teaching Hospital ,Ilorin. Introduction.

Download Presentation

Ademola Popoola , BUHARI TAJUDEEN , Fidelis Ushie , Hamid Olanipekun . Department of Surgery

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Multiple Primary Cancers -simultaneously occurring prostate cancer and other primary tumors: any link or coincidences? AdemolaPopoola ,BUHARI TAJUDEEN ,FidelisUshie ,HamidOlanipekun. Department of Surgery University of Ilorin Teaching Hospital ,Ilorin.

  2. Introduction • Prostate cancer is the most commonly diagnosed malignancy affecting men beyond middle age. • Is the most common non cutaneous malignancy in the Western world. • 2nd leading cause of cancer death in men. • It is a major public health burden in Sub Sahara Africa. • In practice, prostate cancer has been reported to occur simultaneously (synchronous) or successively (metachronous).

  3. Introduction [Cont’d] • Some multiple cancer syndromes have been well defined. These include Von HippelLindau Syndrome (cerebellar & retinal heamangioma, renal, pancreatic and spinal meningeal tumors).

  4. Aim • To report Multiple Primary Cancers (MPC) involving Prostate cancer in our centre in the last two years. • To identify from the literature possible associations of simultaneously occurring cancers.

  5. Methodology • Retrospective analyses from our database of patients with MPC involving prostate cancer in the last two years. • Review of existing literature for possible association.

  6. Discussion

  7. Discussion [Cont’d] • Prostate cancer could occur with other primary tumours as synchronous or metachronous. • This has been adduced to increased life span and improved diagnostic tools. • There are existing literatures reporting prostate cancer occurring with all the other primary tumors in our series. • Lee et al; reported 4.03% finding of prostate cancer in radical cystoprostatectomy specimen (Asian J. Andrology, 2006).

  8. Discussion [Cont’d] • The incidence of other primary tumours in the setting of primary liver cell carcinoma is relatively common with a strong clustering of genitourinary and gastro-intestinal malignancies. • Synchronous thyroid tumours have been reported following radiation for head and neck tumours. In our report, it was discovered after External beam radiation therapy to the pelvis. • Prostate cancer with Rectal cancer - Post Radiotherapy - Age

  9. Discussion [Cont’d] • Prostate cancer with Colonic tumours - Genetics: (i) mutation of BRCA2 gene (ii) mutation of MMR gene (Lynch syndrome)

  10. Challenges • To make Diagnosis. • Diagnostic tools are limited: availability and affordability. • Between oncologic cure and preservation of functional anatomy/quality of life. • No established guideline. • Poor cancer registry. • Low rate of postmortem and radical procedures.

  11. Conclusion • MPC occurrence are probably more than the documented cases. • Detailed clinical evaluation is key. • There is need for more multidisciplinary approach to care. • There is also need for genetics study.

More Related