Emerging Data Regarding the Potential Benefits of Early Initiation of Clopidogrel Among ACS Patients. C. Michael Gibson, M.S., M.D. Inhibition of Platelet Aggregation Following Clopidogrel Administration. Hochholzer W et al. Circulation. 2005;111. Clopidogrel.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
C. Michael Gibson, M.S., M.D.
Hochholzer W et al. Circulation. 2005;111
Clopidogrel Loading Dose Timing and Risk of MACE
Log Odds of Death, MI
or UTVR at 28 Days
P = 0.020
for treatment / timing
Hours Prior to PCI of Study Drug Loading Dose
J Am Coll Cardiol 2006;47:939–43.
Influence of Thienopyridine Exposure – PCI pts Administration
30 Day Primary Endpoint Adverse Events
Not Thienopyridine Exposed
Clopidogrel stopped Administration
prior to CABG
prior to CABGCURE: Major Bleeding in CABG Patients
K.Fox et al, ESC 2002
*Heparin=unfractionated or enoxaparin