Peripheral Chemoreceptor Responsiveness and Hypoxic Pulmonary Vasoconstriction. Tyler J. Albert, M.D. Senior Medical Resident Chief of Medicine Rounds November 23, 2010. 3 Years of Preparation. Intern year:
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Tyler J. Albert, M.D.
Senior Medical Resident
Chief of Medicine Rounds
November 23, 2010
Denervation of peripheral chemoreceptors in animals, diminishing HVR, increases HPV
Carotid body ablation
Naeije et al. JAP 66:42, 1989
Individuals with high HVR
have less HPV in response to
low alveolar oxygen (PAO2).
- SaO2 - Minute ventilation
- HR - End-tidal CO2 (EtCO2)
- BP -ECG
p = 0.01
R2 = 0.41
Naeije R, LeJeune P, Leeman M, Melot C, Closset J. Pulmonary vascular responses to surgical chemodenervation and chemical sympathectomy in dogs. J Appl Physiol. 1989 Jan;66(1):42-50.
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Duffin J. Measuring the ventilatory response to hypoxia. J Physiol. 2007 Oct 1;584(Pt 1):285-93.
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Teppema LJ, Dahan A. The ventilatory response to hypoxia in mamals: mechanisms, measurement, and analysis. Physiol Rev. 2010;90:675-754.
Aaronson PI, Robertson TP, Knock GA, et al. Hypoxic pulmonary vasoconstriction: mechanisms and controversies. J Physiol. 2006;570(1):53-58.
VA Respiratory Therapists
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