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Trends of PCB Isomeric Patterns in Japanese Environmental Media: Risk Assessment

This study investigates the trends of PCB isomeric patterns in Japanese environmental media, food, breast milk, and blood, with a focus on risk assessment. The analysis includes the use of various congeners and the evaluation of PCB levels in different samples over time.

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Trends of PCB Isomeric Patterns in Japanese Environmental Media: Risk Assessment

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  1. Trends of PCB isomeric patterns in Japanese environmental media, food, breast milk and blood in view of risk assessment Takeshi Nakano1, Yoshimasa Konishi2, Rie Masho3 and Chiharu Tohyama4

  2. ２,３,４,７,８－PeCDF ２,３,７,８－TCDD ７５ congeners １３５congeners ７５ congeners ２０９ congeners １,２,３,５,６,７－HxCN ３,４,５,３’,４’－Co-PCB

  3. Trend of PCB Use in Japan Total58,000t Amount of PCB use (t)

  4. PCB product use in Japan 1969-1971 KC-300 400 500 600 Ar-1242 1248 1254 1260

  5. KC300 Japan KC400 Homologue pattern reflects product use KC500 KC600 Japan

  6. PCB Homologue Distribution and Source Estimation

  7. Source estimation KC３００ KC５００ Insulator N.C.P. capacitor Sediment A Sediment B KC４００ KC６００ Ship paint Insulator capacitor

  8. To evaluate environmental risk

  9. Daily variation of PCDD/Fsand PCBs in ambient air

  10. Daily variation of Dioxin Concentration

  11. Time trend of PCDD/F levels in ambient air

  12. Time trend of PCDDs/PCDFs（TEQ） Dioxin Emission Reduction Plan Matsumura et al, symposium of J.Env.Chem, 2003.6

  13. Emission inventry vs Level in air 0.50 1997 0.40 1998 0.30 1999 PCDDs/PCDFs（pg-TEQ/m3) 0.20 2000 0.10 2001 0.00 0 8000 7000 6000 5000 4000 3000 2000 1000 Emission inventry (g-TEQ/year） Matsumura et al, symposium of J.Env.Chem, 2003.6

  14. Time trend of Co-PCBs（TEQ） Matsumura et al, symposium of J.Env.Chem, 2003.6

  15. Time trend of Co-PCBs（TEQ）

  16. Time trend of PCB levels in ambient air(log scale)

  17. 3 ( ng/m ) 3 ( pg/m ) 1000 100 10 1 0.1 0.01 1970 1975 1980 1985 1990 1995 2000 2005 3 Time trend of PCBs concentration in ambient air (ng/m ) 3 Time trend of PCBs concentration in ambient air (pg/m ) Ambient air

  18. Time trend of PCBlevelsin breast milk

  19. µg / g-fat 0.3 0.2 0.1 0 µg g-fat PCB Time trend of breast milk levels 60 40 20 0 60 40 20 0 pg TEQ/g-fat pg TEQ/g-fat Dioxins Year (1973-2000) Year (1973-2000) Konishi et al. (2003) Konishi et al (2003) Organohalogen compds

  20. Development of congener specific analysis for PCBs using HT8-PCB

  21. Congener number number of isomer of peakmono 3 3di 12 10tri 24 23tetra 42 39penta 46 38hexa 42 40hepta 24 23octa 12 12nona 3 3deca 1 1 total 209 192

  22. GC/MS-SIM chromatogram of TrCB (HT8-PCB) PCB product 13C-TrCB Matsumura et al, J. Env. Chem. (2002)

  23. P5CB 800000 Intensity 400000 0 20 22 24 26 28 30 32 34 36 38 Retention Time (min) Calculated Retention Time #104 #103 #100 #102 #121 #101 #113 #112 #119 #117 #125 #116 #111 #120 #110 #124 #109 #107 #123 #106 #118 #114 #122 #105 #127 #126 #96 #94 #93 #98 #95 #88 #91 #92 #84 #89 #90 #99 #83 #86 #97 #87 #85 #82 #108 #115 13C-P5CB 50000 Intensity 0 20 22 24 26 28 30 32 34 36 38 Retention Time (min) GC/MS-SIM chromatogram of PeCB (HT8-PCB) PCB product 13C-PeCB Matsumura et al, J. Env. Chem. (2002)

  24. Congener profiles of PCBsin environmental samples

  25. Congener profiles of PCBs(Di-, Tri-) in environmental samples

  26. Congener profiles of PCBsin environmental and human samples

  27. Congener profiles of PCBs(Hexa-) in environmental and human samples

  28. Congener profiles of PCBs(Hepta-) in environmental and human samples

  29. Congener profiles of PCBsin human samples(breast milk)

  30. #70 PCB product #66 25-25 25-34 25-23 #52 245-4 #44 23-34 #74 #56 #60 245-4 mother milk #74 24-34 #66 234-4 #60 Isomer profiles of TeCB

  31. 236-34 245-25 #101 PCB product 236-25 #110 #118 #95 245-24 #105 #99 245-34 mother milk #118 245-24 #99 234-34 #105 Isomer profiles of PeCB

  32. #153 236-245 PCB product 245-245 #149 234-245 #138 #153 mother milk 245-245 234-245 #138 Isomer profiles of HxCB

  33. #180 PCB product 245-2345 245-2356 #187 234-2345 #170 #180 breast milk 245-2345 245-2356 #187 234-2345 #170 Isomer profiles of HpCB

  34. Congener profiles of PCBsin human samples(pooled blood)

  35. #28 ＃28 Tri-CBs 24-4 ＃31 Tetra-CBs #74 ＃74 245-4 ＃80 Penta-CBs #99 #118 245-34 ＃118 ＃99 245-24 ＃153 Hexa-CBs 245-234 #153 245-245 #138 ＃163/ ＃164 ＃138 Hepta-CBs #187 ＃180 ＃187 245-2345 #180 245-2356 ＃170 Chromatogram of PCB in human blood（3~7Cl） Hirai et al, (2003) Organohalogen compounds

  36. (n=24) Congeners Mean 2S.D. ± Existence Ratio* (BZ#) (ng /g-lipid) (%) #153 28.0 28.0 22.3 ± #180 14.9 16.6 11.8 ± #138 10.4 9.2 8.3 ± #187 8.3 8.5 6.6 ± #118 6.9 5.9 5.5 ± #163,164 6.4 6.2 5.1 ± #99 4.7 4.2 3.8 ± #74 4.6 2.6 3.6 ± #146 4.1 3.7 3.3 ± #170 3.8 4.1 3.0 ± #156 2.8 3.0 2.3 ± Sum 75.6 * Mean is compare to total PCBs level Levels of the predominant PCB congeners in human blood cumulative (%) 22.3 34.1 42.4 49.0 54.5 59.6 63.4 67.0 70.3 73.3 75.6 245-245 245-2345 245-234 245-2356 245-34 245-24 245-4 245-235 2345-234 2345-34 Hirai et al, (2003) Organohalogen compounds

  37. human milk/adipose tissue #153 (2,2',4,4',5,5'-) #74 (2,4,4',5-) #138 (2,2',3,4,4',5'-) #99 (2,2’,4,4',5-) #187 (2,2',3,4’,5,5’,6-) #118 (2,3’,4,4',5-) PCB congeners predominant in human samples

  38. PCB levels andHomologue profiles in Environmental samples

  39. 0.1-10ng/m3 0.1-10ng/L Air Water Sediment Biota 0.1-800ng/g-wet 0.05-800ng/g-dry PCB levels in air, water, sediment and biota (2002, MOE Japan)

  40. Homologue profiles of PCBsin human samples

  41. 50 45 abundance(%) 40 35 30 25 20 15 10 5 0 Air Human blood Water Breast milk Bird

  42. Congener profiles of TrCB,TeCBin human and combustion sample (A)

  43. PCB product PCB product Combustion Combustion Breast milk Breast milk PCB congeners predominant in human samples (TrCB, TeCB)

  44. Congener profiles of TrCB,TeCBin combustion sample (B)

  45. (stack gas) #47 TrCB 24-24 #68 #51 TeCB 24-35 24-26

  46. Congener profiles of PCBin human sample

  47. 12 DL-PCB(TEF)+di-ortho-PCB Predominant PCB in product Contribution of DL-PCBs in breast milk

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