SLEEPING SICKNESS
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SLEEPING SICKNESS. WHAT IS?. SLEEPING SICKNESS IS A PARASITIC DISEASE OF PEOPLE AND ANIMALS, CAUSED BY PROTOZOA OF THE SPECIES TRYPANOSOMA BRUCEI  AND TRANSMITTED BU THE TSETSE FLY. THE DISEASE IS ENDEMIC IN SOME REGIONS OF SUB-SAHARAN AFRICA.

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What is
WHAT IS?

  • SLEEPING SICKNESS IS A PARASITIC DISEASE OF PEOPLE AND ANIMALS, CAUSED BY PROTOZOA OF THE SPECIES TRYPANOSOMA BRUCEI AND TRANSMITTED BU THE TSETSE FLY.

  • THE DISEASE IS ENDEMIC IN SOME REGIONS OF SUB-SAHARAN AFRICA.

  • THE PARASITE IS UNABLE TO SURVIVE IN THE BLOODSTREAM WITHOUT ITS FLAGELLUM.


Signs and symptoms
SIGNS AND SYMPTOMS:

  • AFRICAN TRYPANOSOMIASIS SYMPTOMS OCCURS IN TWO STAGES:

  • THE HAEMOLYMPHATIC PHASE: (FEVER-HEADACHES-JOINT PAINS-ITCHING)

  • THE NEUROLOGICAL PHASE: (CONFUSION-REDUCED COORDINATION-DISRUPTION OF THE SLEEP CYCLE- FATIGE, SLUMBER [DAY-TIME]-INSOMNIA [NIGHT-TIME]

  • TRYPTOPHOL: CHEMICAL COMPOUND THAT INDUCES SLEEP IN HUMANS PRODUCED BY THE TRYPANOSOMAL PARASITE.


Tsetse fly
TSETSE FLY:

  • LARGE, BROWN BITING FLY.

  • HOST AND VECTOR (TRYPANOSOME PARASITES).

  • FIRST, PARASITES ENTER THE LYMPAHATIC SYSTEM, THEM PASS INTO THE BLOODSTREAM AND REPLICATE BY BINARY FISSION.

  • OTHER WAYS TO TAKE THE DISEASE:

  • MOTHER TO CHILD INFECTION

  • LABORATORIES

  • BLOOD TRANSFUSION

  • SEXUAL CONTACT


Prevention
PREVENTION:

THE STRATEGY USED TO CONTROL SLEEPING SICKNES IS DETECTION AND TREATMENT OF NEW INFECTIONS, TSETSE FKY CONTROL.

  • ERADICATION OF THE TSETSE FLY.

  • REDUCE SPREAD OF THE PARASITE.

    SYSTEMATIC SCREENING IS THE BEST OPTION(ENDEMNIC REGIONS). ALLOWS EARLY-STAGE DISEASE TO BE DETECTED AND TREATED BEFORE THE DISEASE PROGRESSES.


Treatment
TREATMENT:

  • IN THE HAEMOLYMPHATIC PHASE:

  • INTRAVENOUS OR INTRAMUSCULAR PENTAMIDINE.

  • INTRAVENOUS SURAMIN.

  • IN THE NEUROLOGICAL PHASE:

  • INTRAVENUS MELARSOPROL 2.2 MG/KG DAILY FOR 12 HOURS.

  • INTRAVENOUS EFLORNITHINE 50 MG/KG EVERY SIX HOURS FOR 14 DAYS.


Spreading
SPREADING:

  • TRYPANOSOMA BRUCEI GAMBIENSE. HUMANS, ALSO IN PIGS AND OTHER ANIMALS. LOCATED IN CENTRAL AND WESTERN AFRICA.

  • TRYPANOSOMA BRUCEI RHODESIENSE. WILD GAME ANIMALS AND CATTLE. LOCATED IN SOUTHERN AND EASTERN AFRICA.

  • OVER 60 MILLION PEOPLE ARE AT RISK OF CONTRACTING THE DISEASE.


RESOURCES:

  • http://en.wikipedia.org/wiki/African_trypanosomiasis

  • http://www.google.es/search?tbm=isch&hl=es&source=hp&biw=1280&bih=675&q=sleeping+sickness&gbv=2&oq=sleeping+sic&aq=0&aqi=g1g-S9&aql=&gs_sm=e&gs_upl=2231l11331l0l13554l14l14l1l1l1l0l287l2484l0.6.6l12l0

    BY:JACQUELINE VALLEJO FERNÁNDEZ


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